ArticleJournal of applied toxicology : JAT2026
Comparative Study of Analgesic Therapeutic Index and Addiction Potential of o- and p-Fluorofentanyl.
Article in Journal of applied toxicology : JAT, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Antinociceptive Effect and Hyperalgesia of Fentanyl and Its Analogues.International journal of molecular sciences · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
As fluorinated fentanyl derivatives, p-fluorofentanyl and o-fluorofentanyl have caused many abuse-related deaths in recent years. However, their pharmacological properties in the body are still unclear, resulting in a lack of targeted control measures for the prevention of abuse and emergency treatment of acute poisoning. This study comprehensively assessed their therapeutic indices and addiction potential using acute toxicity, hot-plate, conditioned place preference (CPP), and naloxone-precipitated withdrawal tests. Results showed that the subcutaneous median lethal dose (95% confidence interval; LD₅₀ [95% CI]) values of o-fluorofentanyl were 101 (76.26-135) mg/kg (female) and 133 (108-264) mg/kg (male), while the LD₅₀ (95% CI) values of p-fluorofentanyl were 76 (54.2-118) mg/kg (female) and 58 (49.2-81.8) mg/kg (male). The acute toxicity of o-fluorofentanyl and p-fluorofentanyl was greatest when administered intravenously, followed by intraperitoneal, subcutaneous, and intragastric gavage. In the hot-plate test, the median effective dose (ED
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Registered trials
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