ArticleRedox biology2026
P7C3-A20 prevents whole brain radiotherapy-induced chronic hippocampal redox imbalance and neuropsychiatric impairment in mice.
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Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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Authors and funding
29 authors.
Edwin Vázquez-RosaDepartment of Psychiatry Case Western Reserve University, Cleveland, OH, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA; Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA; Geriatric Research Education and Clinical Center (GRECC), Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.
Min-Kyoo ShinDepartment of Psychiatry Case Western Reserve University, Cleveland, OH, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA; Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA; Geriatric Research Education and Clinical Center (GRECC), Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 08226, Republic of Korea; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea; Innovative Pharmaceutical Sciences Program, College of Transdisciplinary Innovations, Seoul National University, Seoul, 08826, Republic of Korea; Laboratory of Neurodegenerative Diseases, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
Kalyani ChaubeyDepartment of Psychiatry Case Western Reserve University, Cleveland, OH, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA; Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA; Geriatric Research Education and Clinical Center (GRECC), Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.
Sarah BarkerDepartment of Psychiatry Case Western Reserve University, Cleveland, OH, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA; Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA; Geriatric Research Education and Clinical Center (GRECC), Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.
Sofia G CorellaDepartment of Psychiatry Case Western Reserve University, Cleveland, OH, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA; Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA; Geriatric Research Education and Clinical Center (GRECC), Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.
Suwarna ChakrabortyDepartment of Physiology, Pharmacology & Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sunil Jamuna TripathiDepartment of Physiology, Pharmacology & Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Youngmin YuDepartment of Psychiatry Case Western Reserve University, Cleveland, OH, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA; Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA; Geriatric Research Education and Clinical Center (GRECC), Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA; University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
Jiwon HyungDepartment of Psychiatry Case Western Reserve University, Cleveland, OH, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA; Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA; Geriatric Research Education and Clinical Center (GRECC), Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.
Himanshu DashoraDepartment of Cancer Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Jing HaoDepartment of Cancer Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Coral J Cintrón-PérezDepartment of Psychiatry Case Western Reserve University, Cleveland, OH, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA; Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA; Geriatric Research Education and Clinical Center (GRECC), Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.
Zea BudDepartment of Psychiatry Case Western Reserve University, Cleveland, OH, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA; Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA; Geriatric Research Education and Clinical Center (GRECC), Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA; Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA.
Matasha DharDepartment of Psychiatry Case Western Reserve University, Cleveland, OH, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA; Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA; Geriatric Research Education and Clinical Center (GRECC), Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.
Emiko MillerDepartment of Psychiatry Case Western Reserve University, Cleveland, OH, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA; Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA; Geriatric Research Education and Clinical Center (GRECC), Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.
Yeojung KohDepartment of Psychiatry Case Western Reserve University, Cleveland, OH, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA; Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA; Geriatric Research Education and Clinical Center (GRECC), Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.
Kate P LindleyDepartment of Psychiatry Case Western Reserve University, Cleveland, OH, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA; Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA; Geriatric Research Education and Clinical Center (GRECC), Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA; University of Evansville, Evansville, IN, USA.
Vidya IndrakumarDepartment of Psychiatry Case Western Reserve University, Cleveland, OH, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA; Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA; Geriatric Research Education and Clinical Center (GRECC), Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.
Rocio Aguila RodriguezDepartment of Psychiatry Case Western Reserve University, Cleveland, OH, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA; Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA; Geriatric Research Education and Clinical Center (GRECC), Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.
Kranti A MapuskarFree Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
Joshua D SchoenfeldRadiation Oncology, Dana-Farber Brigham and Women's Cancer Center, New York, NY, USA.
Hisashi FujiokaCryo-Electron Microscopy Core, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Luke I SzwedaSarver Heart Center, University of Arizona Health Sciences, Tucson, AZ, USA.
Brigid M WilsonLouis Stokes Cleveland VA Medical Center, Cleveland, OH, USA; Division of Infectious Diseases and HIV Medicine in the Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Jennifer S YuDepartment of Cancer Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA; Case Comprehensive Cancer Center, Cleveland, OH, USA; Center for Cancer Stem Cell Biology, Cleveland Clinic, Cleveland, OH, USA.
Bindu D PaulDepartment of Physiology, Pharmacology & Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Lieber Institute for Brain Development, Baltimore, MD, USA.
Douglas R SpitzFree Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA; Department of Pathology, University of Iowa, Iowa City, IA, USA.
Bryan G AllenFree Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA.
Andrew A PieperDepartment of Psychiatry Case Western Reserve University, Cleveland, OH, USA; Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA; Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA; Geriatric Research Education and Clinical Center (GRECC), Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA. Electronic address: andrew.pieper@case.edu.
Funding
Viral VectorP30CA086862 · UNIVERSITY OF IOWA · 2000 to 2025
$11.9MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · CASE WESTERN RESERVE UNIVERSITY · 1985 to 2005
$7.3MExploiting Redox Metabolism Using Pharmacological Ascorbate for Cancer TherapyP01CA217797 · NCI · UNIVERSITY OF IOWA · PI Joseph J Cullen, Douglas Robert Spitz · 2022 to 2022
$1.9MNeuroprotective actions of cystathionine g-lyase through gasotransmitter hydrogen sulfide signalingR01AG071512 · JOHNS HOPKINS UNIVERSITY · 2025 to 2025
$660kTRAINING PROGRAM IN FREE RADICAL AND RADIATION BIOLOGYT32CA078586 · UNIVERSITY OF IOWA · 1999 to 2005
$511kCase CCC Youth Engaged in Science, 09/01/2022-08/31/2027R25CA221718 · CASE WESTERN RESERVE UNIVERSITY · 2025 to 2025
$416kThe Alzheimer's Disease Translational Data Science Training ProgramT32AG071474 · CASE WESTERN RESERVE UNIVERSITY · 2025 to 2025
$138kThe Role of Neuronal Primary Cilia Deterioration in Alzheimer's DiseaseF31AG089912 · CASE WESTERN RESERVE UNIVERSITY · 2025 to 2025
$50kNCI NIH HHS P01 CA217797NCI NIH HHS P01 CA244091NCI NIH HHS P30 CA086862NCI NIH HHS R25 CA221718NCI NIH HHS T32 CA078586NIA NIH HHS F31 AG089912NIA NIH HHS F99 AG083111NIA NIH HHS R01 AG071512NIA NIH HHS T32 AG071474NIGMS NIH HHS T32 GM007250
Abstract
Whole brain radiotherapy (WBRT) prolongs survival for patients with brain metastases but produces persistent oxidative injury to the brain and long-term neuropsychiatric sequelae, for which no approved neuroprotective therapies exist. Here, we show that a single course of WBRT produces chronic oxidative stress in mice that persists for at least one year, equivalent to decades in humans, and selectively injures the hippocampus, causing cognitive decline and depressive-like behavior. Daily administration of P7C3-A20, a neuroprotective compound that stabilizes brain nicotinamide adenine dinucleotide (NAD
Indexed as
Cranial IrradiationHippocampusNeuroprotective AgentsAniline CompoundsAnimalsCarbazolesMaleMiceNADOxidation-ReductionOxidative StressAniline CompoundsCarbazolesNADNeuroprotective AgentsP7C3-A20P7C3 compoundDepressionHippocampusNeurodegenerationNeuroprotectionOxidative stressP7C3-A20Whole brain irradiation
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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.