Evidence map›Paper›PMID 41680148›Full record

ArticleNature communications2026

Heritable changes in chromatin contacts associated with transgenerational susceptibility to diet-induced insulin dysregulation and obesity.

Richard C Chang, Riann J Egusquiza, Angélica Amorim Amato, Zhuorui Li, Alivia L Dougherty, Kaitlin T To, Michelle Avila, Erika M Joloya, Hailey B Wheeler, Angela Nguyen and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Richard C Chang *Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0003-3235-1959
Riann J Egusquiza *Department of Pharmaceutical Sciences, University of California Irvine, Irvine, CA, USA.
Angélica Amorim AmatoDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.
Zhuorui LiDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.
Alivia L DoughertyDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.
Kaitlin T ToDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.
Michelle AvilaDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0009-0006-6429-7052
Erika M JoloyaDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-4974-1657
Hailey B WheelerDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.
Angela NguyenDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.
Keiko ShiodaKrantz Family Center for Cancer Research, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, USA.
Junko OdajimaKrantz Family Center for Cancer Research, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, USA.
Michael S LawrenceKrantz Family Center for Cancer Research, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, USA.ORCID http://orcid.org/0000-0002-1307-459X
Toshi ShiodaKrantz Family Center for Cancer Research, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, USA. shioda@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-9434-7835
Bruce BlumbergDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA. blumberg@uci.edu.ORCID http://orcid.org/0000-0002-8016-8414

Funding

NIEHS NIH HHS R01 ES023316U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) NIH R01 ES023316U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) NIH R01 ES031129
6 · The paper itself

Abstract

Effects of prenatal environmental exposures can be transmitted across generations through the germline without DNA mutations, an example of transgenerational epigenetic inheritance. Understanding how such inheritance occurs remains a central unanswered question in biology. Here we show that gestational exposure of mice to the environmental obesogen tributyltin produces heritable changes in chromatin interactions within the Ide gene encoding insulin-degrading enzyme in male primordial germ cells. These altered contacts persist through the F3 generation and are accompanied by reduced hepatic Ide expression, hyperinsulinemia, hyperglycemia and hyperleptinemia, resembling the phenotype of Ide-deficient mice that are predisposed to adult-onset, diet-induced obesity. The formation of new chromatin contacts, suppression of Ide expression, and associated metabolic phenotypes occurs only in males. These findings reveal a plausible molecular mechanism by which environmental exposures induce location-specific, three-dimensional changes in chromatin structure that transmit susceptibility to metabolic disorders to subsequent unexposed generations in mammals.

Indexed as

ChromatinInsulinObesityAnimalsDevelopmental Origins of Health and DiseaseDietDiet, High-FatEpigenesis, GeneticEpigenetic MemoryFemaleHyperinsulinismLiverMaleMiceMice, Inbred C57BLPregnancyChromatinInsulin

Identifiers

PMID41680148
PMCPMC13009398

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.