ArticleGeroScience2026
Cardiorespiratory fitness in relation to cerebral vascular and metabolic health in older adults with coronary artery disease.
Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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14 authors.
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Abstract
This study investigated whether higher cardiorespiratory fitness (VO₂peak) is associated with better cerebral vascular and metabolic health-specifically cerebral blood flow (CBF), cerebrovascular reactivity (CVR), cerebral metabolic rate of oxygen (CMRO₂), and oxygen extraction fraction (OEF) across healthy older adults and patients with coronary artery disease (CAD). Thirty-seven healthy adults (65.3 ± 8.3 years old) and 35 CAD patients (66.4 ± 9.3 years old) underwent calibrated fMRI using hypercapnic and hyperoxic gas challenges (including carbogen) to quantify gray matter CBF, CVR, CMRO₂, and OEF. VO₂peak was obtained from a maximal cycle ergometer cardiopulmonary exercise test. Associations between VO₂peak and brain biomarkers were evaluated with group terms to test CAD-specific effects. Across all participants, VO₂peak was positively associated with CBF (β = 0.32, p = 0.02) and CVR (β = 0.002, p = 0.04) in gray matter, indicating an association between aerobic fitness and vascular health. Metabolic effects differed by group: in CAD patients, VO₂peak correlated positively with CMRO₂ (β = 0.08, p = 0.02), suggesting higher fitness may be associated with preserved oxidative metabolism, while in healthy controls, VO₂peak was negatively associated with OEF (β = -3.6, p = 0.02), consistent with aging-related adaptations driven by improved CBF without CMRO₂ changes. VO₂peak is positively associated with cerebral vascular function in older adults and shows group-specific metabolic benefits: in CAD, higher VO₂peak relates to preserved CMRO₂, whereas in healthy individuals it is linked primarily to enhanced perfusion and reduced extraction. These findings support aerobic exercise as a promising strategy to mitigate CAD-related brain alterations and highlight VO₂peak as a potentially modifiable target for prevention and rehabilitation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.