Evidence map›Paper›PMID 41680643›Full record

ArticleBMC cancer2026

Comprehensive analysis of tissue-derived small extracellular vesicles transcriptomic and extensively targeted lipidomics from patients with high-grade serous ovarian cancer.

Mengdi Fu, Jinhui Wang, Hao Wu, Peng Peng, Dongyan Cao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mengdi FuNational Clinical Research Center for Women's Health and Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Jinhui WangNational Clinical Research Center for Women's Health and Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Hao WuDepartment of General Surgery, Beijing Hospital, National Center for Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Peng Peng *National Clinical Research Center for Women's Health and Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. pengp1999@163.com.
Dongyan Cao *National Clinical Research Center for Women's Health and Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. caodongyan@pumch.cn.

Funding

Beijing Kanghua foundation for the development of traditional Chinese and western medicine KH-2021-LQJJ-001National Key Technology Research and Developmental Program of China 2022YFC2704400the National Key Clinical Specialty Construction Project U114000
6 · The paper itself

Abstract

backgroundTissue-derived small extracellular vesicles (Ti-sEVs) are critical components of the tumor microenvironment. Nonetheless, the biological functions and potential clinical significance of Ti-sEVs lncRNAs and mRNAs in ovarian cancer have not been studied.

methodsWe collected 5 high-grade serous ovarian cancer specimen, 5 benign ovarian tumors, and 5 normal ovarian tissue specimens. Ti-sEVs were isolated, and high-throughput sequencing of lncRNA and mRNA and lipid metabolites of the three groups were performed. RT-qPCR confirmed the expression of lncRNA RMRP derived from Ti-sEVs of ovarian cancer. The prognostic value and immune cell infiltration were further analyzed.

resultsThe lncRNAs and mRNAs profiles of Ti-sEVs in ovarian cancer patients exhibited distinct differences from those in healthy controls and benign patients. The functions of the differential lncRNAs and mRNAs were related to immune response and metabolic reprogramming. The expression of RMRP was further verified in vitro. Public database analysis found that RMRP levels were associated with the prognosis of patients with ovarian cancer. The study found that the expression of RMRP was positively correlated with neutrophils.

conclusionThese findings revealed the Ti-sEVs transcriptome and extensively targeted lipidome characteristics from ovarian cancer patients, and comprehensive analysis showed that RMRP has the potential to become a promising prognostic biomarker candidate.

Indexed as

Cystadenocarcinoma, SerousExtracellular VesiclesLipidomicsOvarian NeoplasmsTranscriptomeBiomarkers, TumorFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMiddle AgedNeoplasm GradingPrognosisRNA, Long NoncodingRNA, MessengerTumor MicroenvironmentBiomarkers, TumorRNA, Long NoncodingRNA, MessengerExtracellular vesiclesLncRNAOvarian cancerRMRP

Identifiers

PMID41680643
PMCPMC13011482

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.