ArticleParasites & vectors2026
LAG3 constrains anti-parasitic response by effector CD4
Article in Parasites & vectors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
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Abstract
backgroundImmune checkpoint molecules such as lymphocyte activation gene-3 (LAG3) play a critical role in modulating host-pathogen interactions during chronic parasitic infections; however, their functions in early infection remain poorly defined. Using a murine model infected with Echinococcus multilocularis (E. multilocularis), a lethal helminth causing alveolar echinococcosis (AE), we elucidate the stage-specific regulatory functions of LAG3 in CD4
methodsEchinococcus multilocularis-infected mice were employed as the experimental model. Flow cytometry was used to analyze LAG3 expression on CD4
resultsWe found that LAG3 was predominantly expressed on hepatic effector CD4
conclusionsOur study reveals a previously unrecognized role for LAG3 as an immune checkpoint during early E. multilocularis infection, highlighting its function in limiting anti-parasitic CD4
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