ArticleWorld journal of surgical oncology2026
Effects of major solid cancer surgery on oxidative stress assessed by plasma xanthine oxidase and adenosine deaminase activity : a pilot study.
Article in World journal of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSolid cancers and their surgical treatment are both major sources of oxidative stress (OS), which contributes to adverse clinical outcomes. This study aimed to explore the impact of major solid cancer surgery on plasma OS concentrations by assessing key biomarkers.
methodsWe conducted an exploratory, prospective study including 36 patients undergoing elective major cancer surgery. Pre- and postoperative plasma concentrations of adenosine deaminase (ADA), xanthine oxidase (XO), ischemia-modified albumin (IMA), redox potential (RP), and high-sensitivity troponin T (hs-TnT) were measured. Thirty matched healthy controls were used for comparison.
resultsPreoperative plasma concentrations of ADA, XO, IMA, and RP were significantly elevated in patients, as compared to controls, indicating high baseline oxidative stress. Postoperatively, plasma concentrations of XO, IMA, and RP decreased significantly (p < 0.05) but remained higher than those of controls, while ADA concentrations showed no significant postoperative decrease. The plasma concentration of hs-TnT increased modestly but significantly after surgery (p = 0.003). A negative correlation between preoperative ADA and XO concentration was observed (r = -0.46; p = 0.006).
conclusionSolid cancers were associated with elevated plasma expression of OS, which significantly decreased after surgery. However, major surgery itself induces a residual oxidative burden, reflected by an elevation in myocardial biomarkers. The increased levels of OS levels before surgery could fit the cancer-driven "priming/second-hit" framework. The negative correlation between ADA and XO suggests a potential feedback mechanism. These findings bring new insights regarding OS modulation during major solid cancer surgery and warrant further investigation in larger studies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.