Evidence mapPaperPMID 41681908Full record

ReviewCancers2026

Chemoprevention in Skin Cancer: What Advice?

Ariadna Ortiz-Brugués, Carmen Orte Cano, Lluis Corbella, Francesc Alamon-Reig, Ignasi Martí-Martí, Maria Ayguasanosa-Avila, Marc Hernández-Santacana, Priscila Giavedoni, Paula Aguilera, Cristina Carrera

Abstract readReview
In one paragraph

Review in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ariadna Ortiz-BruguésHospital Clínic Barcelona, 08036 Barcelona, Spain.
Carmen Orte CanoDepartment of Dermatology, Hôpital Erasme, Université Libre de Bruxelles (ULB), HUB, 1070 Brussels, Belgium.ORCID 0000-0002-1570-7856
Lluis CorbellaHospital Clínic Barcelona, 08036 Barcelona, Spain.ORCID 0000-0003-4072-1083
Francesc Alamon-ReigHospital Clínic Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-6018-9680
Ignasi Martí-MartíHospital Clínic Barcelona, 08036 Barcelona, Spain.
Maria Ayguasanosa-AvilaHospital Clínic Barcelona, 08036 Barcelona, Spain.
Marc Hernández-SantacanaHospital Clínic Barcelona, 08036 Barcelona, Spain.
Priscila GiavedoniHospital Clínic Barcelona, 08036 Barcelona, Spain.
Paula AguileraHospital Clínic Barcelona, 08036 Barcelona, Spain.
Cristina CarreraHospital Clínic Barcelona, 08036 Barcelona, Spain.ORCID 0000-0003-1608-8820

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of melanoma and non-melanoma skin cancers (NMSCs) is increasing worldwide. While NMSCs are more common, melanoma remains the most challenging because of its higher aggressiveness. Although the use of sunscreens is key in high-risk populations, it provides limited protection, which highlights the need for alternative solutions. In this review, we discuss current evidence on chemopreventive therapies, as well as their efficacy and adverse events, including immunocompetent and immunosuppressed patients. Acitretin, nicotinamide, 5-fluorouracil, and photodynamic therapy have shown overall promising results in actinic keratosis and squamous cell carcinoma. Nevertheless, more research is needed to establish their efficacy, particularly in melanoma, Merkel cell carcinoma, and cutaneous lymphoma, due to their higher mortality rates.

Indexed as

5-fluorouracilactinic keratosischemopreventionmelanomanicotinamidenon-melanoma skin cancerphotodynamic therapyretinoidsskin cancersolid organ transplant recipients

Identifiers

PMID41681908
PMCPMC12896719

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.