Evidence map›Paper›PMID 41682606›Full record

ReviewJournal of clinical medicine2026

Intracardiac Echocardiography in Structural Heart Interventions: A Comprehensive Overview.

Francesco Leuzzi, Ciro Formisano, Enrico Cerrato, Antongiulio Maione, Tiziana Attisano, Francesco Meucci, Michele Ciccarelli, Carmine Vecchione, Gennaro Galasso, Francesca Maria Di Muro

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Francesco LeuzziDepartment of Medicine, Surgery, and Dentistry, University of Salerno, 84084 Salerno, Italy.
Ciro FormisanoDepartment of Medicine, Surgery, and Dentistry, University of Salerno, 84084 Salerno, Italy.
Enrico CerratoInterventional Cardiology Unit, San Luigi Gonzaga University Hospital, 10043 Orbassano, Italy.ORCID 0000-0002-1260-7534
Antongiulio MaioneCardiology Unit, Cardiovascular and Thoracic Department, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", 84131 Salerno, Italy.
Tiziana AttisanoCardiology Unit, Cardiovascular and Thoracic Department, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", 84131 Salerno, Italy.
Francesco MeucciDepartment of Structural Interventional Cardiology, Careggi University Hospital, 50134 Florence, Italy.
Michele CiccarelliDepartment of Medicine, Surgery, and Dentistry, University of Salerno, 84084 Salerno, Italy.ORCID 0000-0003-2379-1960
Carmine VecchioneDepartment of Medicine, Surgery, and Dentistry, University of Salerno, 84084 Salerno, Italy.
Gennaro GalassoDepartment of Medicine, Surgery, and Dentistry, University of Salerno, 84084 Salerno, Italy.ORCID 0000-0002-7265-7613
Francesca Maria Di MuroDepartment of Medicine, Surgery, and Dentistry, University of Salerno, 84084 Salerno, Italy.ORCID 0000-0002-2145-6555

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracardiac echocardiography (ICE) is increasingly recognized as a valuable imaging modality in structural heart interventions, offering high-resolution, real-time visualization from within the cardiac chambers. Originally developed for electrophysiologic procedures, ICE has expanded its use across a broad spectrum of structural interventions, including atrial septal defect (ASD) and patent foramen ovale (PFO) closure, left atrial appendage occlusion (LAAO), transseptal puncture guidance, transcatheter edge-to-edge repair (TEER), balloon mitral valvuloplasty, and both mitral and tricuspid valve therapies. This review outlines the current role and technical principles of ICE, with an emphasis on catheter design, image acquisition protocols, and the emerging potential of 3D ICE. Comparisons with transesophageal echocardiography (TEE) and fluoroscopy are discussed, highlighting ICE's ability to support minimally invasive, sedation-sparing procedures while maintaining procedural precision. We provide a focused analysis of ICE-guided applications in specific clinical scenarios, emphasizing its role in anatomical assessment, device navigation, and intra-procedural monitoring. Data from recent clinical studies and registries are reviewed to assess safety, feasibility, and outcomes. Practical considerations including operator learning curve, workflow integration, and limitations such as cost and field of view are also addressed. Lastly, we explore future directions including advanced 3D imaging, fusion imaging, artificial intelligence integration, and robotic catheter systems.

Indexed as

intracardiac echocardiographyprocedural planningprocedurestructural heart disease

Identifiers

PMID41682606
PMCPMC12898507

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.