Evidence mapPaperPMID 41682804Full record

ReviewJournal of clinical medicine2026

Premenstrual Syndrome and Nutritional Factors: A Narrative Review of Current Evidence and Clinical Implications.

Francesco Giuseppe Martire, Eugenia Costantini, Ilaria Ianes, Claudia d'Abate, Maria De Bonis, Emilio Piccione, Angela Andreoli

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Francesco Giuseppe MartireDepartment of Molecular and Developmental Medicine, Obstetrics and Gynecological Clinic, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-0756-535X
Eugenia CostantiniDepartment of Molecular and Developmental Medicine, Obstetrics and Gynecological Clinic, University of Siena, 53100 Siena, Italy.ORCID 0009-0001-0325-6744
Ilaria IanesDepartment of Molecular and Developmental Medicine, Obstetrics and Gynecological Clinic, University of Siena, 53100 Siena, Italy.
Claudia d'AbateDepartment of Molecular and Developmental Medicine, Obstetrics and Gynecological Clinic, University of Siena, 53100 Siena, Italy.ORCID 0009-0004-4688-9228
Maria De BonisDepartment of Molecular and Developmental Medicine, Obstetrics and Gynecological Clinic, University of Siena, 53100 Siena, Italy.ORCID 0009-0000-3170-9125
Emilio PiccioneGynecology and Obstetrics, Department of Surgical Sciences, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0002-7647-0688
Angela AndreoliClinical Nutrition Unit, Department of System Medicine, Department of Surgical Sciences, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0001-8730-7862

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Premenstrual syndrome is a common hormone-related condition marked by recurrent physical and affective symptoms that can substantially impair daily functioning. While cyclical ovarian hormone fluctuations are physiological, clinically relevant symptoms occur only in a subset of women, indicating the contribution of individual vulnerability and modifiable environmental factors. In this context, growing attention has been directed toward the role of nutrition. This narrative review synthesizes and critically discusses current evidence on the relationship between dietary factors and premenstrual syndrome, with emphasis on both primary prevention and symptom modulation. Available observational and interventional data suggest that dietary patterns characterized by high intake of ultra-processed foods, refined carbohydrates, and saturated fats are more frequently associated with increased symptom severity, whereas healthier dietary patterns may be linked to a lower symptom burden. Certain micronutrients-including calcium, vitamin D, zinc, iron, and omega-3 fatty acids-have demonstrated potential benefits, although findings remain heterogeneous and methodologically limited. Overall, nutrition emerges as a plausible complementary strategy in premenstrual syndrome management; however, well-designed prospective studies are needed to support robust, evidence-based dietary recommendations.

Indexed as

complementary therapynutritional factorpremenstrual syndromepreventionsymptoms

Identifiers

PMID41682804
PMCPMC12898590

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.