Evidence mapPaperPMID 41683511Full record

ArticleMolecules (Basel, Switzerland)2026

Multifaceted Anticancer Activity of Flavanone/Chromanone Intermediates for Five-Membered Heterocyclic Derivatives: Targeting Oxidative Stress, Apoptosis, and MAPK Signaling in Colorectal Cancer.

Pawel Hikisz, Angelika A Adamus-Grabicka, Elzbieta Budzisz

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pawel HikiszDepartment of Oncobiology and Epigenetics, Institute of Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Angelika A Adamus-GrabickaDepartment of Bioinorganic Chemistry, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.ORCID 0000-0003-0119-599X
Elzbieta BudziszDepartment of the Chemistry of Cosmetic Raw Materials, Medical University of Lodz, 90-151 Lodz, Poland.ORCID 0000-0001-9949-8723

Funding

Medical University of Lodz 503/3-066-02/503-31-001National Science Center 2023/07/X/NZ3/01404National Science Center 2024/08/X/NZ7/01232
6 · The paper itself

Abstract

This study explores the multifaceted anticancer mechanisms of flavanone analogues and spiropyrazoline condensed with flavanone ring against colorectal cancer (CRC) cell lines. Five-membered heteroaromatic scaffolds, in particular, have gained prominence in medicinal chemistry as they offer enhanced metabolic stability, solubility and bioavailability, crucial factors in developing effective drugs. Building upon previous findings, we investigated three lead derivatives (

Indexed as

Antineoplastic AgentsApoptosisColorectal NeoplasmsFlavanonesHeterocyclic CompoundsMAP Kinase Signaling SystemOxidative StressCell Line, TumorCell ProliferationHumansReactive Oxygen SpeciesAntineoplastic AgentsflavanoneFlavanonesHeterocyclic CompoundsReactive Oxygen Speciesanticancer propertiesapoptosiscolon carcinomafive-membered scaffoldsflavonoid derivativesgenotoxicityMAPK pathwayNrf2pyrazolinesreactive oxygen species

Identifiers

PMID41683511
PMCPMC12899987

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.