Evidence map›Paper›PMID 41683531›Full record

ArticleMolecules (Basel, Switzerland)2026

A UHPLC-Orbitrap-MS Metabolomics Strategy Reveals Glycerophospholipid Metabolic Remodeling Is Associated with the Anti-Arthritic Effect of Glycyrrhiza Protein-Paeoniflorin Nanoparticles via PI3K/AKT/NLRP3 Axis.

Na Zhang, Xiaoyun Yang, Cui Li, Miaoxin Huo, Yuan Gao, Dong Bai, Yuqin Yang

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Na ZhangInstitute of Basic Theory of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Xiaoyun YangInstitute of Basic Theory of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Cui LiInstitute of Basic Theory of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Miaoxin HuoInstitute of Basic Theory of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Yuan GaoInstitute of Basic Theory of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Dong BaiInstitute of Basic Theory of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Yuqin YangInstitute of Basic Theory of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Funding

Science and Technology Innovation Project, Chinese Academy of Traditional Chinese Medicine (KYG-202409the Independent Topic Selection Research Project of the Institute of Basic Theory of Chinese Medicine, China Academy of Chinese Medical Sciences YZX-202232the National Natural Science Foundation of China Youth Program 81403282the Science and Technology Innovation Project of the China Academy of Chinese Medical Sciences CI2021A0O108
6 · The paper itself

Abstract

Rheumatoid arthritis involves chronic synovitis and immune-metabolic dysregulation, highlighting a need for multi-target therapies that jointly modulate metabolism and inflammation. We developed glycyrrhiza protein-paeoniflorin self-assembled nanoparticles (GP-PF NPs) and investigated their anti-arthritic mechanism in adjuvant-induced arthritis (AIA) mice, using UHPLC-Orbitrap-MS-based metabolomics. Male C57BL/6 mice (

Indexed as

Arthritis, ExperimentalGlucosidesGlycerophospholipidsGlycyrrhizaMetabolomicsMonoterpenesNanoparticlesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAnimalsChromatography, High Pressure LiquidMaleMass SpectrometryMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinGlucosidesGlycerophospholipidsMonoterpenesNLR Family, Pyrin Domain-Containing 3 ProteinPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktglycerophospholipid metabolismglycyrrhiza protein–paeoniflorin nanoparticlesPI3K/AKT/mTOR pathwayrheumatoid arthritisUHPLC-Orbitrap-MS metabolomics

Identifiers

PMID41683531
PMCPMC12899346

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.