Evidence map›Paper›PMID 41683566›Full record

ArticleInternational journal of molecular sciences2026

InCytokine, an Open-Source Software, Reveals a TREM2 Variant-Specific Cytokine Signature.

Deepak Jha, Marco Ancona, Filip Oplt, Sonia L Farmer, Martin Vagenknecht, Alejandro Vazquez-Otero, Illia Prazdnyk, Jindrich Soukup, Rebecca S Mathew, Vanessa Peterson and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Deepak JhaData and Genome Sciences, Merck & Co., Inc., Boston, MA 02115, USA.ORCID 0000-0002-6657-5662
Marco AnconaApplied Research and Innovation, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.ORCID 0000-0003-4935-0071
Filip OpltData Science and Scientific Informatics, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.
Sonia L FarmerData and Genome Sciences, Merck & Co., Inc., Boston, MA 02115, USA.
Martin VagenknechtData Science and Scientific Informatics, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.
Alejandro Vazquez-OteroApplied Research and Innovation, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.
Illia PrazdnykApplied Research and Innovation, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.
Jindrich SoukupData Science and Scientific Informatics, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.
Rebecca S MathewData and Genome Sciences, Merck & Co., Inc., Boston, MA 02115, USA.
Vanessa PetersonData and Genome Sciences, Merck & Co., Inc., Boston, MA 02115, USA.
Danny A BittonApplied Research and Innovation, MSD Czech Republic s.r.o., 150 00 Prague, Czech Republic.ORCID 0000-0003-3282-1017

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytokine and chemokine profiling is central to understanding inflammatory processes and the mechanisms driving diverse diseases. We introduce InCytokine, an open-source tool for semiquantitative analysis of cytokine and chemokine data generated by protein array technologies. InCytokine features robust and modular image-processing workflows, including automated spot detection, template alignment, normalization, quality control measures, and quantitative intensity summarization to deliver consistent and reliable readouts from profiling assays. We evaluated InCytokine by profiling wild-type microglia, TREM2 knockout, and Alzheimer's disease-associated

Indexed as

CytokinesMembrane GlycoproteinsReceptors, ImmunologicSoftwareAlzheimer DiseaseAnimalsHumansLipopolysaccharidesMiceMicrogliaProtein Array AnalysisCytokinesLipopolysaccharidesMembrane GlycoproteinsReceptors, ImmunologicTREM2 protein, humanAlzheimer’s diseasebiomarkercytokines profilingDPP4protein arrayTREM2

Identifiers

PMID41683566
PMCPMC12897140

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.