Evidence map›Paper›PMID 41683745›Full record

ArticleInternational journal of molecular sciences2026

Oxidative Stress and Endothelial Dysfunction in Patients with Hypertensive Nephropathy: Role of the Mediterranean Diet.

Luca Salomone, Danilo Menichelli, Irene Azzara, Pierluigi Maria Damosso, Vittoria Cammisotto, Valentina Castellani, Pasquale Pignatelli, Elena Pacella, Anna Paola Mitterhofer, Francesca Tinti and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Luca SalomoneNephrology Unit, Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0009-0006-1929-3044
Danilo MenichelliDepartment of General Surgery, Surgical Specialty and Anesthesiology, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-9467-5903
Irene AzzaraNephrology Unit, Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Pierluigi Maria DamossoOphthalmology Unit, Department of Sense Organs, Sapienza University of Rome, 00185 Rome, Italy.
Vittoria CammisottoDepartment of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-1966-5945
Valentina CastellaniDepartment of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-6455-4828
Pasquale PignatelliDepartment of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-2265-7455
Elena PacellaOphthalmology Unit, Department of Sense Organs, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-5431-6399
Anna Paola MitterhoferNephrology Unit, Department of Systems Medicine, Tor Vergata Universisty of Rome, 00133 Rome, Italy.
Francesca TintiNephrology Unit, Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-8867-3979
Silvia LaiNephrology Unit, Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-7199-2954

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Essential hypertension is a leading cause of chronic kidney disease (CKD) and is frequently complicated by hypertensive nephropathy, characterized by nephroangiosclerosis and increased intrarenal vascular resistance, assessable by renal resistive index (RRI). Oxidative stress and endothelial dysfunction contribute to CKD progression, and the Mediterranean diet (MD) has been associated with a more favorable oxidative and endothelial profile, although data linking diet to renal microcirculation in hypertensive nephropathy remain limited. The aim of this study is to evaluate the relationship between RRI, oxidative stress, endothelial function, and adherence to the Mediterranean diet in patients with essential hypertension and hypertensive nephropathy. We performed a cross-sectional single-center study and we enrolled 99 patients with essential hypertension, hypertensive nephropathy, and CKD stages G1-G4 (KDIGO). All patients underwent laboratory testing, measurement of oxidative stress markers (sNOX2-dp, H

Indexed as

Diet, MediterraneanEndothelium, VascularHypertension, RenalNephritisOxidative StressAgedBiomarkersCross-Sectional StudiesFemaleHumansKidneyMaleMiddle AgedBiomarkersendothelial dysfunctionhypertensive nephropathyMed-Dietoxidative stress

Identifiers

PMID41683745
PMCPMC12898065

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.