Evidence map›Paper›PMID 41683808›Full record

ArticleInternational journal of molecular sciences2026

Heparan Sulfates Regulate Vascular Reactivity in Syndecan 1 Knockout Mice.

Simone R Potje, Aishwarya Katiki, Paulo W Pires, Andreia Zago Chignalia

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Simone R PotjeDepartment of Medical Sciences, Minas Gerais State University, Passos 37900-106, MG, Brazil.ORCID 0000-0001-8848-5118
Aishwarya KatikiDepartment of Anesthesiology, College of Medicine-Tucson, University of Arizona, Tucson, AZ 85724, USA.
Paulo W PiresDepartment of Physiology, College of Medicine-Tucson, University of Arizona, Tucson, AZ 85724, USA.ORCID 0000-0001-5972-4554
Andreia Zago ChignaliaDepartment of Anesthesiology, College of Medicine-Tucson, University of Arizona, Tucson, AZ 85724, USA.

Funding

FAPESP 2018/01853-0FAPESP 2019/06653-2
6 · The paper itself

Abstract

Heparan sulfates (HS) are polysaccharides abundantly expressed in the extracellular matrix and the glycocalyx of endothelial cells, having a putative role in vascular function. The role of HS in vascular reactivity remains unclear. Herein, we sought to determine whether HS regulate the vascular tone in physiological conditions. Using male, 6-8-weeks-old, CD1, C57BL/6, syndecan 1 (

Indexed as

Heparan SulfateSyndecan-1AnimalsAortaGlypicansMaleMiceMice, Inbred C57BLMice, KnockoutPolysaccharide-LyasesSyndecan-2Syndecan-4GlypicansHeparan Sulfateheparitinsulfate lyasePolysaccharide-LyasesSdc1 protein, mouseSyndecan-1Syndecan-2Syndecan-4glypican 1heparan sulfateheparinase IIIsyndecan 1vascular reactivity

Identifiers

PMID41683808
PMCPMC12897610

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.