Evidence mapPaperPMID 41683890Full record

ReviewInternational journal of molecular sciences2026

Carbon Dots and Mitochondria-Advances in Targeting, Imaging, and Therapeutics.

Aasia Bibi, Daniela De Benedictis, Giuseppe Capitanio, Alessandra Gabriele, Amer Ahmed, Mariapompea Cutroneo, Lorenzo Torrisi, Daniela Manno, Antonio Serra, Domenico De Rasmo and 1 more

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aasia BibiDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, 70124 Bari, Italy.ORCID 0000-0002-7005-2346
Daniela De BenedictisDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, 70124 Bari, Italy.ORCID 0009-0008-9129-6578
Giuseppe CapitanioDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, 70124 Bari, Italy.ORCID 0000-0002-9369-4608
Alessandra GabrieleCEDAD-Centro di Fisica Applicata Datazione e Diagnostica-Dipartimento di Matematica e Fisica "E. De Giorgi", Università del Salento, Via Arnesano, 73100 Lecce, Italy.ORCID 0000-0003-0212-873X
Amer AhmedDepartment of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, 70125 Bari, Italy.ORCID 0000-0002-0503-4045
Mariapompea CutroneoDipartimento MIFT, Università di Messina, Viale F.S. d'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0002-8416-8454
Lorenzo TorrisiDipartimento MIFT, Università di Messina, Viale F.S. d'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0003-0853-136X
Daniela MannoCEDAD-Centro di Fisica Applicata Datazione e Diagnostica-Dipartimento di Matematica e Fisica "E. De Giorgi", Università del Salento, Via Arnesano, 73100 Lecce, Italy.ORCID 0000-0002-5843-8772
Antonio SerraCEDAD-Centro di Fisica Applicata Datazione e Diagnostica-Dipartimento di Matematica e Fisica "E. De Giorgi", Università del Salento, Via Arnesano, 73100 Lecce, Italy.ORCID 0000-0003-3380-7751
Domenico De RasmoCNR-Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, 70124 Bari, Italy.
Anna SignorileDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, 70124 Bari, Italy.

Funding

Ministry of University and Research of Italy (MUR-Italy) F61B23000370006MUR-Italy CUP F61B23000370006
6 · The paper itself

Abstract

Carbon dots (CDs), a class of fluorescent nanomaterials, have emerged as powerful tools for biological applications, particularly in the targeting, imaging, and therapeutic modulation of mitochondria. Due to their small size, simplicity of synthesis, biocompatibility, and tunable optical properties, CDs can be engineered to selectively accumulate in mitochondria, enabling real-time imaging of mitochondrial function and dynamics in live cells. Moreover, their ability to carry therapeutic agents, such as antioxidants, drugs, and gene delivery vectors, offers potential in treating mitochondrial dysfunction, which is central to various diseases, including neurodegenerative disorders, cancer, and metabolic diseases. Recent advancements in surface functionalization have enhanced mitochondrial targeting and specificity, while ongoing research aims to optimize the safety, efficiency, and clinical translation of CDs for therapeutic applications. This review highlights the latest developments in the use of carbon dots for mitochondrial imaging, therapeutic delivery, and disease intervention, offering promising avenues for future research and clinical applications.

Indexed as

Carbon Quantum DotsMitochondriaAnimalsDrug Delivery SystemsHumansNeoplasmsNeurodegenerative DiseasesCDs (carbon dots)imagingmitochondriatherapeutics

Identifiers

PMID41683890
PMCPMC12897841

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.