ArticleInternational journal of molecular sciences2026
Clinical Significance of Cytokeratin 19-Fragments (CYFRA 21-1), Osteopontin (OPN) and Human Epididymis Protein 4 (HE4) in Pancreatic Adenocarcinoma.
Augustin Catalin Dima, Daniel Vasile Balaban, Iulia-Ioana Stanescu-Spinu, Ana Teodorescu, George Manucu, Laura Ioana Coman, Alina Dima, Cezar Betianu, Mihai Tanase, Daniela Miricescu and 2 more
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In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Augustin Catalin DimaClinical Department 14, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Daniel Vasile BalabanClinical Department 5, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0000-0003-3436-8041 Iulia-Ioana Stanescu-SpinuDiscipline of Physiology, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Ana TeodorescuDepartment of Gastroenterology, Carol Davila Central University Emergency Military Hospital, 010825 Bucharest, Romania.
George ManucuDepartment of Gastroenterology, Carol Davila Central University Emergency Military Hospital, 010825 Bucharest, Romania.
Laura Ioana ComanDepartment of Gastroenterology, Carol Davila Central University Emergency Military Hospital, 010825 Bucharest, Romania.
Alina DimaClinical Department 5, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0000-0001-8743-3236 Cezar BetianuDepartment of Radiology, Doctor Carol Davila Central Military University Emergency Hospital, 010825 Bucharest, Romania.
Mihai TanaseDepartment of Surgery 2, Carol Davila University Central Emergency Military Hospital, 010825 Bucharest, Romania.
Daniela MiricescuDiscipline of Biochemistry, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Mariana JingaClinical Department 5, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0000-0001-5826-0815 Catalin CarstoiuClinical Department 14, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Pancreatic cancer remains one of the most aggressive digestive neoplasms, especially due to late diagnosis. The aim of our study was to investigate cytokeratin-19 fragments (CYFRA 21-1), osteopontin (OPN), and human epididymis protein 4 (HE4) clinical significance in pancreatic adenocarcinoma. Our research is a single-center cross-sectional prospective study that included sixty hospitalized patients diagnosed with pancreatic adenocarcinoma and fourteen controls. CYFRA 21-1, OPN, and HE4 were tested in all participants using Luminex x MAP technology. Serum CYFRA 21-1 levels were weakly correlated with those of OPN (r = 0.302;
Indexed as
AdenocarcinomaAntigens, NeoplasmBiomarkers, TumorKeratin-19OsteopontinPancreatic NeoplasmsWAP Four-Disulfide Core Domain Protein 2AdultAgedCase-Control StudiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedProspective Studiesantigen CYFRA21.1Antigens, NeoplasmBiomarkers, TumorKeratin-19OsteopontinWAP Four-Disulfide Core Domain Protein 2WFDC2 protein, humanbiomarkerCYFRA 21-1human epididymis protein 4osteopontinpancreatic cancer
Identifiers
PMID41683979
PMCPMC12898393
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