Evidence map›Paper›PMID 41683984›Full record

ArticleInternational journal of molecular sciences2026

Combined Approach of Chromatographic Fractionation and Raman Spectroscopy for Metabolite Profiling of

Elizaveta Denisova, Anastasia Avdyusheva, Vera Vasilieva, Elizaveta Tyshchuk, Polina Grebenkina, Andrey Korenevsky, Ivan Chelibanov, Vladimir Chelibanov, Areg Totolian, Lyudmila Kraeva and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Characterization of theInternational journal of molecular sciences · 2026
    Article
  2. Characterization of theInternational journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Elizaveta DenisovaSaint-Petersburg Pasteur Institute, St. Petersburg 197101, Russia.ORCID 0000-0003-3034-8262
Anastasia AvdyushevaResearch Institute of Obstetrics and Gynecology Named After D.O. Ott, St. Petersburg 199034, Russia.
Vera VasilievaResearch Institute of Obstetrics and Gynecology Named After D.O. Ott, St. Petersburg 199034, Russia.
Elizaveta TyshchukSaint-Petersburg Pasteur Institute, St. Petersburg 197101, Russia.
Polina GrebenkinaSaint-Petersburg Pasteur Institute, St. Petersburg 197101, Russia.ORCID 0000-0002-5229-9732
Andrey KorenevskySaint-Petersburg Pasteur Institute, St. Petersburg 197101, Russia.ORCID 0000-0002-0365-8532
Ivan ChelibanovSaint-Petersburg Pasteur Institute, St. Petersburg 197101, Russia.
Vladimir Chelibanov«OPTEK» Joint Stock Company, St. Petersburg 199178, Russia.
Areg TotolianSaint-Petersburg Pasteur Institute, St. Petersburg 197101, Russia.ORCID 0000-0003-4571-8799
Lyudmila KraevaSaint-Petersburg Pasteur Institute, St. Petersburg 197101, Russia.ORCID 0000-0002-9115-3250
Dmitry SokolovSaint-Petersburg Pasteur Institute, St. Petersburg 197101, Russia.ORCID 0000-0002-5749-2531

Funding

Russian Science Foundation 24-15-00002
6 · The paper itself

Abstract

The secretome of ESKAPE pathogens contains numerous bioactive molecules that play a key role in pathogenesis and the formation of an immunosuppressive microenvironment. However, analyzing this complex chemical composition presents significant methodological challenges. In this study, we propose a combined approach integrating chromatographic fractionation of cell-free supernatants with Raman spectroscopy to deconstruct the secretome of the clinically relevant Gram-negative pathogen-

Indexed as

EnterobacterMetabolomeMetabolomicsSecretomeSpectrum Analysis, RamanChromatographybacterial secretomechromatographic fractionationESKAPE pathogensRaman spectroscopyvirulence metabolites

Identifiers

PMID41683984
PMCPMC12898628

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.