Evidence map›Paper›PMID 41684014›Full record

ReviewInternational journal of molecular sciences2026

Alcohol-Induced Dysregulation of Hydrogen Sulfide Signaling in Alzheimer's Disease-

Constantin Munteanu, Cristina Popescu, Andreea-Iulia Vlădulescu-Trandafir, Francisco Maraver, José Manuel Carbajo, Gelu Onose

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Constantin MunteanuGrigore T. Popa University of Medicine and Pharmacy Iași, 700115 Iași, Romania.ORCID 0000-0002-1084-7710
Cristina PopescuUniversity of Medicine and Pharmacy "Carol Davila", 020022 Bucharest, Romania.ORCID 0000-0002-5703-985X
Andreea-Iulia Vlădulescu-TrandafirUniversity of Medicine and Pharmacy "Carol Davila", 020022 Bucharest, Romania.ORCID 0000-0003-1369-3873
Francisco MaraverMedical Hydrology Group, Department of Radiology and Rehabilitation, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0003-3818-6624
José Manuel CarbajoMedical Hydrology Group, Department of Radiology and Rehabilitation, Complutense University of Madrid, 28040 Madrid, Spain.
Gelu OnoseUniversity of Medicine and Pharmacy "Carol Davila", 020022 Bucharest, Romania.ORCID 0000-0002-6346-8941

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alcohol use disorder (AUD) is highly comorbid with psychiatric conditions and is increasingly recognized as a modifiable factor associated with cognitive decline and dementia, including Alzheimer's disease (AD). While epidemiological and experimental studies consistently demonstrate that chronic alcohol exposure exacerbates neurodegenerative vulnerability rather than implying a single dominant causal pathway, accumulating evidence supports a multifactorial and context-dependent framework in which alcohol acts as a disease-modifying stressor that perturbs endogenous adaptive and resilience mechanisms. Hydrogen sulfide (H

Indexed as

AlcoholismAlzheimer DiseaseEthanolHydrogen SulfideSignal TransductionAnimalsHumansMitochondriaOxidative StressEthanolHydrogen Sulfidealcohol consumptionAlzheimer’s disease (AD)gasotransmittershomocysteinehydrogen sulfide (H2S)mitochondrial dysfunctionneurodegenerationneuroinflammationoxidative stress

Identifiers

PMID41684014
PMCPMC12898331

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.