ArticleImmunity, inflammation and disease2026
Predictors of Intravenous Immunoglobulin Non-Responsiveness in Children With Kawasaki Disease.
Article in Immunity, inflammation and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Predictors of Intravenous Immunoglobulin Non-Responsiveness in Children With Kawasaki Disease.Immunity, inflammation and disease · 2026Article
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2 authors.
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Abstract
backgroundThis retrospective study assesses whether the systemic immune-inflammation index (SII) is a better predictor of intravenous immunoglobulin (IVIG) non-responsiveness (IVIG-NR) in children with Kawasaki disease (KD children) than the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR).
methodsAfter 458 pediatric KD patients were categorized as IVIG responders or non-responders, blood test data were collected from both groups prior to IVIG administration. Upon SII, NLR, and PLR calculation, IVIG-NR predictive performances of these markers were evaluated through receiver operating characteristic curve evaluation, and IVIG-NR risk factors (RFs) were determined by multivariate logistic regression.
resultsCompared to IVIG responders, the non-responders showed significantly higher NLR, PLR, and SII (p-values < 0.05). The cut-off values of these markers for optimal IVIG-NR prediction were 4.245, 147.736, and 1465.238, respectively.
conclusionAlthough all three of them were the independent RFs for IVIG-NR in KD children, SII was a better IVIG-NR predictor than NLR and PLR.
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