Evidence map›Paper›PMID 41684211›Full record

ArticleAnnals of clinical and translational neurology2026

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease.

Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I Bohnen, Roger L Albin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Taylor BrownDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Giulia CarliMorris K. Udall Center of Excellence for Parkinson's Disease Research, University of Michigan, Ann Arbor, Michigan, USA.
Prabesh KanelDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Stiven RoytmanDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Jaimie BarrDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Nicolaas I BohnenDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Roger L AlbinMorris K. Udall Center of Excellence for Parkinson's Disease Research, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0002-0629-608X

Funding

Udall Catalyst Research Project: Retrosplenial Cholinergic and Attentional-Motor Integration DysfunctionP50NS123067 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AHMED, OMAR JAMIL · 2021 to 2025
$11.6M
Public Outreach and Education CoreP50NS091856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAUER, WILLIAM T. · 2014 to 2019
$10.1M
Central cholinergic presbyvestibulopathy network changes and imbalance in Parkinson's disease and older personsR01AG073100 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 2021 to 2025
$3.0M
NIA NIH HHS R01 AG073100NIA NIH HHS R01AG073100NINDS NIH HHS P50 NS091856NINDS NIH HHS P50NS091856NINDS NIH HHS P50 NS123067NINDS NIH HHS P50NS123067NINDS NIH HHS R21NS144749Parkinson's FoundationRRD VA I01 RX001631RRD VA I01 RX003397University of MichiganVA I01RS003397VA I01RX001631
6 · The paper itself

Abstract

objectiveCognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross-sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ligand [

methodsSeventy-five non-demented, mild-moderate PD subjects underwent baseline [

resultsWhole-brain voxel analyses revealed class-specific [

interpretationBaseline cholinergic system changes associate with varying cognitive trajectories in mild-moderate PD. Assessment of regional cholinergic deficits may be useful for prediction of cognitive trajectories in this population, enhancing subject selection and stratification for intervention trials aimed at improving cognition in PD.

Indexed as

BrainCognitive DysfunctionParkinson DiseaseVesicular Acetylcholine Transport ProteinsAgedDisease ProgressionFemaleHumansMaleMiddle AgedPiperidinesPositron-Emission Tomographyfluoroethoxy-benzovesamicolPiperidinesVesicular Acetylcholine Transport Proteinsacetylcholinemild cognitive impairmentParkinson

Identifiers

PMID41684211
PMCPMC13394599

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.