Evidence map›Paper›PMID 41684451›Full record

ArticleFrontiers in endocrinology2025

Placental mRNA and miRNA dynamics associated with lipid metabolism pathways in pregnancies affected by obesity.

Ruggero Spadafora, Jiayi Zhang, N R Nirmala, Xue Li, Perrie O'Tierney-Ginn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ruggero SpadaforaWoman, Mother + Baby Research Institute, Tufts Medical Center, Boston, MA, United States.
Jiayi ZhangDepartment of Data Analytics, Tufts University, Boston, MA, United States.
N R NirmalaInstitute for Clinical Research and Health Policy Studies (ICRHPS) Tufts Medical Center, Boston, MA, United States.
Xue LiTufts Technology Services Research Technology, Tufts University, Medford, MA, United States.
Perrie O'Tierney-GinnWoman, Mother + Baby Research Institute, Tufts Medical Center, Boston, MA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Maternal obesity (pregravid body mass index >30 kg/m Methods: We used unbiased Results: We identified positive correlations between members of the Rho network, a key inflammation regulator, with maternal leptin and cord blood free fatty acids (cbFFA). Furthermore, we identified negative correlations between epigenetic regulators and the lipid metabolism drivers Discussion: Further studies are required to investigate the role that the Rho network plays in placental inflammation and the link between miRNAs and the predisposition towards cardiovascular diseases in the offspring of obese mothers.

Indexed as

Lipid MetabolismMicroRNAsObesityPlacentaPregnancy ComplicationsPregnancy in ObesityRNA, MessengerAdultFemaleHumansPregnancyMicroRNAsRNA, Messengerfree fatty acidsmaternal obesitymicroRNAplacentatranscriptome

Identifiers

PMID41684451
PMCPMC12890621

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.