ArticleInfection prevention in practice2026
Evaluation of the efficacy of the automatic ozone decontamination device in a real-life setting of an intravitreal injection room.
Article in Infection prevention in practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Objective: The objective of this study was to evaluate the efficacy of an ozonation system for disinfecting intravitreal injection rooms. Design: A prospective intervention pilot study was conducted with a 'before-and-after' design. Setting: The study was conducted in an intravitreal injection room at Hospital de Manises. Methods: Air and surface samples were taken before and after ozonation using a remote-controlled ozonation system. The room was treated with ozone at a concentration of 9-10 ppm for 20 min. Measurements were taken immediately after, 12 h, and 24 h post ozonation. Statistical analysis was performed using the Wilcoxon signed-rank test. Results: At 24 h post ozonation, significant reductions in microbial load were observed: in the centre of the room, the bacterial load reduced from >250 colony-forming units (cfu) to 10 cfu (96%) and fungi from 14 cfu to <1 cfu (93.1%) ( Conclusions: In a dedicated intravitreal injection room, a remotely controlled ozonation cycle at 9-10 ppm for 20 min was associated with substantial short-term reductions in airborne and selected surface microbial load under unoccupied conditions. Automated ozonation may complement routine cleaning and ventilation to maintain low environmental bioburden; its clinical impact remains to be determined.
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