Evidence map›Paper›PMID 41685152›Full record

ArticleActa pharmaceutica Sinica. B2026

Multifunctional extracellular vesicles inhibiting autophagy ameliorate immunotherapy in non-small cell lung cancer.

Simiao Wang, Jiayi Chen, Yaxin Cui, Jianming Xing, Jiayi Liu, Hao Jiang, Hongqun Yang, Huan Zhang, Man Sun, Jialin Li and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Simiao WangSchool of Life Sciences, Jilin University, Changchun 130012, China.
Jiayi ChenSchool of Life Sciences, Jilin University, Changchun 130012, China.
Yaxin CuiSchool of Life Sciences, Jilin University, Changchun 130012, China.
Jianming XingSchool of Life Sciences, Jilin University, Changchun 130012, China.
Jiayi LiuSchool of Life Sciences, Jilin University, Changchun 130012, China.
Hao JiangSchool of Life Sciences, Jilin University, Changchun 130012, China.
Hongqun YangDepartment of Endoscopy Center, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
Huan ZhangSchool of Life Sciences, Jilin University, Changchun 130012, China.
Man SunSchool of Life Sciences, Jilin University, Changchun 130012, China.
Jialin LiDepartment of Thoracic Surgery, The First Hospital of Jilin University, Changchun 130021, China.
Wei LiuDepartment of Thoracic Surgery, The First Hospital of Jilin University, Changchun 130021, China.
Zhou ChenSchool of Mechanical and Power Engineering, Nanjing Tech University, Nanjing 211800, China.
Wei SunDepartment of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Xiaobing WangState Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Zhaogang YangSchool of Life Sciences, Jilin University, Changchun 130012, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The modulation of tumor autophagy to enhance antitumor immunity has garnered significant attention, underscoring its critical role in cancer immunotherapy. However, advanced strategies for precise autophagy-regulating drug delivery remain a pressing need. Here, we introduce a targeted small extracellular vesicles (sEVs)-based drug delivery system capable of simultaneously loading antibodies and nucleic acid drugs while ensuring their accurate release in the tumor microenvironment (TME). We developed a dual-stimulation electroporation system that integrates nanosecond electric pulses and ultrasound to enhance sEV production, yielding

Indexed as

AutophagyCancer immunotherapyDrug deliveryEngineered extracellular vesiclesInterleukin-7Non-small cell lung cancerPD-L1Tumor microenvironment

Identifiers

PMID41685152
PMCPMC12891861

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.