Evidence map›Paper›PMID 41685153›Full record

ArticleActa pharmaceutica Sinica. B2026

Carboxylated prodrug of capsaicin with enhanced peripheral nerve permeation mediated by monocarboxylate transporters for long-lasting local anesthesia.

Yu Wen, Tian Yang, Qi Li, Xiaosi Li, Xiaoyan Ma, Huiyang Hu, Prabhakar Busa, Sayma Alam, Libo Tan, Chao Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yu WenDepartment of Chemical and Biological Engineering, University of Alabama, Tuscaloosa, AL 35487, USA.
Tian YangDepartment of Chemical and Biological Engineering, University of Alabama, Tuscaloosa, AL 35487, USA.
Qi LiDepartment of Chemical and Biological Engineering, University of Alabama, Tuscaloosa, AL 35487, USA.
Xiaosi LiDepartment of Chemical and Biological Engineering, University of Alabama, Tuscaloosa, AL 35487, USA.
Xiaoyan MaDepartment of Chemical and Biological Engineering, University of Alabama, Tuscaloosa, AL 35487, USA.
Huiyang HuDepartment of Chemical and Biological Engineering, University of Alabama, Tuscaloosa, AL 35487, USA.
Prabhakar BusaDepartment of Chemical and Biological Engineering, University of Alabama, Tuscaloosa, AL 35487, USA.
Sayma AlamDepartment of Human Nutrition and Hospitality Management, University of Alabama, Tuscaloosa, AL 35487, USA.
Libo TanDepartment of Human Nutrition and Hospitality Management, University of Alabama, Tuscaloosa, AL 35487, USA.
Chao ZhaoDepartment of Chemical and Biological Engineering, University of Alabama, Tuscaloosa, AL 35487, USA.

Funding

Equipment Supplement - Cold triggered Local Anesthesia for Pain ManagementR01GM144388 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Chao Zhao · 2022 to 2026
$1.8M
Nanoparticles with Two-Stage Delivery of Tetrodotoxin for Prolonged Duration Local AnesthesiaR61NS123196 · NINDS · UNIVERSITY OF ALABAMA IN TUSCALOOSA · PI ZHAO, CHAO · 2022 to 2023
$653k
Nanoparticles with Two-Stage Delivery of Tetrodotoxin for Prolonged Duration Local AnesthesiaR33NS123196 · NINDS · UNIVERSITY OF ALABAMA IN TUSCALOOSA · PI ZHAO, CHAO · 2024 to 2024
$364k
NIGMS NIH HHS R01 GM144388NINDS NIH HHS R33 NS123196NINDS NIH HHS R61 NS123196
6 · The paper itself

Abstract

Perineurally injected nerve-blocking agents have limited capability to cross peripheral nerve barriers (PNBs), requiring high doses to block pain signals on axons. This increases the risk of local tissue toxicity and systemic side effects on the cardiovascular and neurological systems. To address this, we explored carboxyl group modification to enhance the permeability of nerve-blocking agents across the PNBs through carrier-mediated transport facilitated by monocarboxylate transporters (MCTs). The enhanced permeability allows for targeted drug delivery to peripheral nerve axons, resulting in a significant reduction in the necessary drug dosage for a long-lasting nerve block. Specifically, we developed a carboxylated prodrug of capsaicin (COOH-CAP) by conjugating it with a carboxyl group

Indexed as

Capsaicin analogueLocal anestheticLong-lasting local anesthesiaMonocarboxylate transporter 1Nerve barrier penetrationProdrugSensory nerve blockadeTRPV1

Identifiers

PMID41685153
PMCPMC12891859

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.