Evidence map›Paper›PMID 41685166›Full record

ArticleActa pharmaceutica Sinica. B2026

The Kv4.3 channel on c-low threshold mechanoreceptors in DRG is a key mediator transforming tactile stimuli into nociceptive signals in chemotherapy-induced neuropathy.

Jiali Zhang, Xiangyu Wang, Xingang Liu, Jincan Li, Kening Qiao, Jinglei Sun, Jiabao Zuo, Weidong Zhao, Tenghui He, Xuedong Li and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jiali ZhangDepartment of Pharmacology, School of Pharmacy, Hebei Medical University, Shijiazhuang 050000, China.
Xiangyu WangCollege of Pharmacy, Hebei Medical University, Shijiazhuang 050000, China.
Xingang LiuCollege of Pharmacy, Hebei Medical University, Shijiazhuang 050000, China.
Jincan LiDepartment of Pharmacology, School of Pharmacy, Hebei Medical University, Shijiazhuang 050000, China.
Kening QiaoDepartment of Pharmacology, School of Pharmacy, Hebei Medical University, Shijiazhuang 050000, China.
Jinglei SunDepartment of Pharmacology, School of Pharmacy, Hebei Medical University, Shijiazhuang 050000, China.
Jiabao ZuoDepartment of Pharmacology, School of Pharmacy, Hebei Medical University, Shijiazhuang 050000, China.
Weidong ZhaoDepartment of Pharmacology, School of Pharmacy, Hebei Medical University, Shijiazhuang 050000, China.
Tenghui HeDepartment of Pharmacology, School of Pharmacy, Hebei Medical University, Shijiazhuang 050000, China.
Xuedong LiCollege of Pharmacy, Hebei Medical University, Shijiazhuang 050000, China.
Zhengkun GuanDepartment of Cardiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Yang ZhangCollege of Pharmacy, Hebei Medical University, Shijiazhuang 050000, China.
Yanfang XuDepartment of Pharmacology, School of Pharmacy, Hebei Medical University, Shijiazhuang 050000, China.
Qingzhong JiaDepartment of Pharmacology, School of Pharmacy, Hebei Medical University, Shijiazhuang 050000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxaliplatin, a chemotherapeutic agent commonly used in colorectal cancer treatment, frequently induces chemotherapy-induced peripheral neuropathy (CIPN), with mechanical allodynia as a dose-limiting neurological complication. However, the precise pathophysiological mechanism underlying this sensory dysfunction remains inadequately elucidated. This study identifies Kv4.3 channel dysfunction in C-low threshold mechanoreceptors (C-LTMRs), a subset of tyrosine hydroxylase-positive (TH

Indexed as

Chemotherapy-induced peripheral neuropathyC-LTMRsKv4.3Mechanical allodyniaOxaliplatin

Identifiers

PMID41685166
PMCPMC12891895

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.