Evidence map›Paper›PMID 41685341›Full record

ArticleMediators of inflammation2026

PSMA4 as a Druggable Target in Hidradenitis Suppurativa: Evidence From Mendelian Randomization and Single-Cell Transcriptomics.

Siqing Guo, Li Gao, Yanting Sun, Lixin Yin, Peihong Li, Boyun Sun, Jingen Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Siqing GuoDepartment of Proctology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn.ORCID https://orcid.org/0009-0004-0686-7702
Li GaoShanghai Fengxian District Traditional Chinese Medicine Hospital, Shanghai, China.
Yanting SunDepartment of Proctology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn.
Lixin YinDepartment of Proctology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn.ORCID https://orcid.org/0000-0002-4779-873X
Peihong LiDepartment of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn.ORCID https://orcid.org/0000-0001-7448-0324
Boyun SunDepartment of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn.ORCID https://orcid.org/0000-0003-0584-7780
Jingen LuDepartment of Proctology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn.ORCID https://orcid.org/0009-0000-9112-4372

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with limited treatment options and frequent drug resistance. Novel therapeutic targets are urgently needed. We performed a druggable genome-wide Mendelian randomization (MR) analysis using blood cis-expression quantitative trait locus (eQTL) and HS genome-wide association study (GWAS) data. Colocalization, transcriptomic validation, single-cell RNA sequencing, and cell-cell communication analyses were integrated to explore gene function and cell-type specificity. We identified eight genes that showed significant associations with HS through MR analysis. Colocalization analysis further prioritized PSMA4 and MAST3 as the most promising druggable targets for HS. Specifically, PSMA4 (single nucleotide polymorphisms [SNPs] = 10; inverse-variance weighted [IVW] OR = 1.912, 95% CI: 1.492-2.450,

Indexed as

Hidradenitis SuppurativaGenome-Wide Association StudyHumansMendelian Randomization AnalysisPolymorphism, Single NucleotideQuantitative Trait LociSingle-Cell AnalysisTranscriptomehidradenitis suppurativainflammationMendelian randomizationtherapeutic targets

Identifiers

PMID41685341
PMCPMC12891442

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.