Evidence map›Paper›PMID 41685360›Full record

ArticleMaterials today. Bio2026

Exercise-mimetic electrical stimulation of muscles triggered by sonopiezoelectric therapy promotes functional repair of abdominal wall defects.

Qian Wu, Yisi Liu, Heng Song, Zhicheng Song, Hekai Shi, Dongchao Yang, Xiaoyu Peng, Binbin He, Junliang Ma, Fengxuan Han and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qian WuDepartment of General Surgery, Huadong Hospital, Fudan University, Shanghai, 200040, PR China.
Yisi LiuOrthopedic Institute, Department of Orthopedic Surgery, Medical 3D Printing Center, The First Affiliated Hospital, MOE Key Laboratory of Geriatric Diseases and Immunology, School of Basic Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, PR China.
Heng SongDepartment of General Surgery, Huadong Hospital, Fudan University, Shanghai, 200040, PR China.
Zhicheng SongDepartment of General Surgery, Huadong Hospital, Fudan University, Shanghai, 200040, PR China.
Hekai ShiDepartment of General Surgery, Huadong Hospital, Fudan University, Shanghai, 200040, PR China.
Dongchao YangDepartment of General Surgery, Huadong Hospital, Fudan University, Shanghai, 200040, PR China.
Xiaoyu PengDepartment of General Surgery, Huadong Hospital, Fudan University, Shanghai, 200040, PR China.
Binbin HeDepartment of General Surgery, Huadong Hospital, Fudan University, Shanghai, 200040, PR China.
Junliang MaDepartment of General Surgery, Huadong Hospital, Fudan University, Shanghai, 200040, PR China.
Fengxuan HanOrthopedic Institute, Department of Orthopedic Surgery, Medical 3D Printing Center, The First Affiliated Hospital, MOE Key Laboratory of Geriatric Diseases and Immunology, School of Basic Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, PR China.
Bin LiOrthopedic Institute, Department of Orthopedic Surgery, Medical 3D Printing Center, The First Affiliated Hospital, MOE Key Laboratory of Geriatric Diseases and Immunology, School of Basic Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, PR China.
Yan GuDepartment of General Surgery, Huadong Hospital, Fudan University, Shanghai, 200040, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current clinical approaches for abdominal wall defects (AWD) caused by extensive myofascial tissue loss employ synthetic meshes for fibrotic tissue repair, but fail to restore complete functionality. Under physiological conditions, rhythmic contractions of abdominal wall muscles during respiration generate endogenous bioelectric cues essential for muscle action potentials and cellular behavior. Therefore, we aimed to develop an exercise-mimetic electrical stimulation (ES) triggered by sonopiezoelectric therapy (SPT) to promote functional repair of AWD. To achieve this, a sandwich-like piezoelectric patch (PCP) was fabricated by sandwiching a chitin mat between two polycaprolactone mats. The three-layer structure mimics lateral abdominal muscle microarchitecture and provides topographical cues for myoblast alignment and fusion. Under respiratory-induced mechanical deformation, the PCP patches generate ES, helping restore local electric field homeostasis. Additionally, low-intensity pulsed ultrasound (LIPUS) can be applied to deliver more precise and intensified stimulation, further promoting myogenic differentiation and myoblast fusion in both

Indexed as

Abdominal wall defectsElectric stimulationExercise-mimeticRegenerationSonopiezoelectric therapy

Identifiers

PMID41685360
PMCPMC12890830

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.