Evidence map›Paper›PMID 41685367›Full record

ArticleMaterials today. Bio2026

3D-printed titanium scaffolds coated with a multifunctional photothermal-responsive hydrogel promote osteoporotic bone defect repair.

Chenchen Wang, Yuan Wang, Xiaojun Li, Hao Cao, Chenfeng Wang, Sheng Han, Haotian Chen, Xin Zhao, Shude Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chenchen WangDepartment of Chemical Engineering and Energy Technology, Shanghai Institute of Technology, Shanghai, 201418, China.
Yuan WangDepartment of Chemical Engineering and Energy Technology, Shanghai Institute of Technology, Shanghai, 201418, China.
Xiaojun LiShanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China.
Hao CaoDepartment of Chemical Engineering and Energy Technology, Shanghai Institute of Technology, Shanghai, 201418, China.
Chenfeng WangCenter of Plastic and Cosmetic Surgery, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, Liaoning, 110002, China.
Sheng HanDepartment of Chemical Engineering and Energy Technology, Shanghai Institute of Technology, Shanghai, 201418, China.
Haotian ChenCenter of Plastic and Cosmetic Surgery, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, Liaoning, 110002, China.
Xin ZhaoShanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China.
Shude YangCenter of Plastic and Cosmetic Surgery, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, Liaoning, 110002, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoporotic bone defects are difficult to repair since conventional titanium scaffolds lack bioactivity and cannot overcome impaired osteogenesis, chronic inflammation, oxidative stress, and cellular senescence. To address these limitations, a multifunctional tannic acid (TA)-based hydrogel coating was developed for 3D-printed titanium alloy scaffolds. The hydrogel was formed from TA, acrylamide, and 3-acrylamidophenylboronic acid, with osteogenic growth peptide (OGP) as a bioactive component. Prussian blue (PB) nanoparticles and quercetin (QUE) were incorporated to provide dynamic crosslinking, photothermal conversion, antioxidant, and anti-inflammatory functions. Stromal cell-derived factor-1α (SDF-1α) was further integrated to recruit endogenous stem cells. The coating exhibited enhanced antiwear and self-healing properties, while near-infrared irradiation (NIR) triggered PB-mediated photothermal effects, thereby improving biotribological performance and accelerating self-repair.

Indexed as

Cellular senescenceHydrogel coatingOsteoporotic bone defectPhotothermal-responsionTitanium scaffolds

Identifiers

PMID41685367
PMCPMC12890852

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.