Evidence map›Paper›PMID 41685608›Full record

ArticleChemistry & biodiversity2026

New Compounds From the Deep-sea Sponge Mycale lingua.

H Poppy Clark, David Horsley, Amanda Serpell-Stevens, Tammy Horton, Ann I Larsson, Emmanuel Tope Oluwabusola, Rainer Ebel, Laurence H De Clippele, Marcel Jaspars

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

H Poppy ClarkMarine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Scotland, UK.ORCID https://orcid.org/0000-0002-1667-9922
David HorsleyInstitute of Medical Sciences, Liberty Building, Foresterhill, University of Aberdeen, Scotland, UK.
Amanda Serpell-StevensNational Oceanography Centre, Southampton, UK.ORCID https://orcid.org/0009-0009-1153-3033
Tammy HortonNational Oceanography Centre, Southampton, UK.ORCID https://orcid.org/0000-0003-4250-1068
Ann I LarssonTjärnö Marine Laboratory, Department of Marine Sciences, University of Gothenburg, Strömstad, Sweden.
Emmanuel Tope OluwabusolaMarine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Scotland, UK.ORCID https://orcid.org/0000-0003-3153-4323
Rainer EbelMarine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Scotland, UK.ORCID https://orcid.org/0000-0002-9702-2235
Laurence H De ClippeleSchool of Biodiversity, One Health & Veterinary Medicine, University of Glasgow, Scotland, UK.ORCID https://orcid.org/0000-0002-4097-274X
Marcel JasparsMarine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Scotland, UK.ORCID https://orcid.org/0000-0002-2426-6028

Funding

ASSEMBLE Plus AmpLOPHELIA project 730984Biotechnology and Biological Sciences Research Council BB/M010996/1Department for Environment, Food and Rural Affairs, UK Government DEEPENDDepartment for Environment, Food and Rural Affairs, UK Government GCBC
6 · The paper itself

Abstract

Three compatible solutes and one compound of unknown ecological function were isolated and characterized from the deep-sea sponge Mycale lingua (Bowerbank, 1866), collected from Tisler reef in Norway. These included the first isolation of asterubine and sulcatin from M. lingua as well as two new sulcatin analogues, sulcatin B and sulcatin C, which have not previously been reported from natural sources. Compound structures were elucidated through high-resolution liquid chromatography-mass spectrometry, and one- and two-dimensional nuclear magnetic resonance spectroscopic methods. All four compounds were tested in tau-tau aggregation assays to determine if they had potential for the treatment of Alzheimer's disease. No activity was displayed in either the cell-free or cell-based tau aggregation assays for any of the compounds.

Indexed as

Biological ProductsPoriferaAnimalsHumansMagnetic Resonance SpectroscopyMolecular Structuretau ProteinsBiological Productstau Proteinschemical ecologydrug discoveryMycale linguanatural products

Identifiers

PMID41685608
PMCPMC12903071

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.