Evidence map›Paper›PMID 41686194›Full record

ArticleDiabetologia2026

Novel deuterium metabolic imaging technique reveals distinct patterns of postprandial hepatic glucose homeostasis in individuals with type 1 diabetes and healthy control individuals: a case-control study.

Alessandro Brunasso, Naomi F Lange, Simone Poli, Michele Schiavon, David Herzig, Chiara Dalla Man, Roland Kreis, Lia Bally

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Article in Diabetologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Alessandro BrunassoDepartment of Information Engineering, University of Padova, Padova, Italy.ORCID http://orcid.org/0009-0003-8067-0417
Naomi F LangeDepartment of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0002-9519-4949
Simone PoliMagnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0001-5676-3187
Michele SchiavonDepartment of Information Engineering, University of Padova, Padova, Italy.ORCID http://orcid.org/0000-0001-6124-5915
David HerzigDepartment of Diabetes, Endocrinology, Nutritional Medicine and Metabolism (UDEM), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0003-1028-9445
Chiara Dalla ManDepartment of Information Engineering, University of Padova, Padova, Italy.ORCID http://orcid.org/0000-0002-4908-0596
Roland KreisMagnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0002-8618-6875
Lia BallyDepartment of Diabetes, Endocrinology, Nutritional Medicine and Metabolism (UDEM), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Lia.bally@insel.ch.ORCID http://orcid.org/0000-0003-1993-7672

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung PCEGP3_186978
6 · The paper itself

Abstract

aims/hypothesisSubcutaneous insulin delivery in individuals with insulin-deficient type 1 diabetes bypasses the portal circulation, disrupting the physiological porto-systemic insulin gradient and affecting postprandial hepatic glucose regulation. However, direct, non-invasive measurement of these liver-specific dynamics and their deviation from normal physiology in individuals with type 1 diabetes is challenging. To address this, we integrated metabolic imaging with whole-body tracer dilution to map postprandial glucose metabolism in both the liver and systemically in adults with type 1 diabetes and healthy control individuals.

methodsIn this cross-sectional study, ten adults with type 1 diabetes and ten healthy control individuals with similar age, BMI and gender distributions were enrolled. After an overnight fast, participants ingested 60 g [6,6'-

resultsAt baseline, individuals with type 1 diabetes had significantly higher plasma glucose concentrations than control individuals (10.7±2.3 and 5.2±0.4 mmol/l, respectively; p<0.001), while preprandial glycogen levels did not differ significantly. Following D-Glc administration, hepatic D-Glc increased more markedly in the individuals with type 1 diabetes compared with the control group (peak values 4.7±2.0 and 3.0±0.8 mmol/l, respectively; p=0.02). In the postprandial period, glycogen levels did not significantly rise at 150 min in type 1 diabetes, whereas a clear increase was observed in control individuals (iAUC CONCLUSIONS/

interpretationBy integrating DMI/

Indexed as

DeuteriumDiabetes Mellitus, Type 1GlucoseLiverAdultBlood GlucoseCase-Control StudiesCross-Sectional StudiesFemaleHomeostasisHumansInsulinMalePostprandial PeriodYoung AdultBlood GlucoseDeuteriumGlucoseInsulinDeuterium metabolic imagingEndogenous glucose productionGlucose fluxesGlucose metabolismGlycogenInsulin sensitivityLiver glucose metabolismMagnetic resonance spectroscopyStable isotopesType 1 diabetes

Identifiers

PMID41686194
PMCPMC13005865

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.