Evidence map›Paper›PMID 41686402›Full record

ArticleClinical rheumatology2026

Geriatric nutritional risk index and mortality risk in elderly patients with rheumatoid arthritis: evidence from NHANES (1999-2018).

Shaoqin Zhang, Haihong Wang, Zexu Jin, Xin Cai

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Article in Clinical rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Shaoqin ZhangThe First People's Hospital of Guiyang, Guiyang, 550001, China.
Haihong WangThe First People's Hospital of Guiyang, Guiyang, 550001, China.
Zexu JinThe First People's Hospital of Guiyang, Guiyang, 550001, China.
Xin CaiThe First People's Hospital of Guiyang, Guiyang, 550001, China. xin.cai@126.com.ORCID http://orcid.org/0009-0007-3563-1696

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No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRheumatoid arthritis (RA) could increase all-cause and cardiovascular mortality, particularly in elderly patients. Malnutrition is usually found in RA and contributes to poorer outcomes, with geriatric nutritional risk index (GNRI) serving as a dependable indicator to provide information on nutritional risk in elderly populations. We aim to elucidate connection between GNRI and survival outcomes in elderly RA patients.

methodsUsing NHANES database from 1999-2018, 1,473 RA patients ≥ 60 years old have been chosen. Participants were categorized into High-GNRI and Low-GNRI group with a threshold of 98. Mortal status was extracted from the Linked Mortality Files. Cox regression was utilized to further assess the relationship.

resultsHigher GNRI was significantly associated with lower all-cause (HR 0.563, 95% CI 0.423-0.751, p < 0.001) and cardiovascular mortality (HR 0.571, 95% CI 0.345-0.946, p = 0.030) in fully adjusted models, which was confirmed by Kaplan-Meier survival curves. Subgroup analyses further validated these associations across various demographic and clinical groups.

conclusionHigher GNRI is independently associated with a lower risk of all-cause and cardiovascular mortality in elderly RA patients, underscoring the importance of nutritional status in the survival of this population. Key Points • Higher GNRI was significantly associated with lower all-cause and cardiovascular mortality in elderly patients with rheumatoid arthritis. • Restricted cubic spline analysis revealed a linear association, with mortality risk decreasing as GNRI increased.

Indexed as

Arthritis, RheumatoidCardiovascular DiseasesGeriatric AssessmentMalnutritionNutritional StatusNutrition AssessmentAgedAged, 80 and overFemaleHumansKaplan-Meier EstimateMaleMiddle AgedNutrition SurveysProportional Hazards ModelsRisk FactorsGeriatric nutritional risk indexMortalityNHANESOlder adultsRheumatoid arthritis

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.