Evidence mapPaperPMID 41686573Full record

ReviewMedicine2026

Global research status of the impact of neutrophil extracellular traps on tumor from 2004 to 2023: A bibliometric and visualized analysis.

Xinyi Wang, Yafen Wang, Yipin Yang, Chao Wu, Enba Zhuo, Mengyao Yin, Mengyuan Zhou, Kangsheng Gu, Bangjie Chen, Yiwen Jia

Abstract readReview
In one paragraph

Review in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xinyi WangDepartment of Gastroenterology, The Third Affiliated Hospital of Anhui Medical University (Hefei First People's Hospital), Hefei, Anhui, China.
Yafen WangDepartment of Radiation Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Yipin YangDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Chao WuDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Enba ZhuoDepartment of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Mengyao YinFirst Clinical Medical College, Anhui Medical University, Hefei, Anhui, China.
Mengyuan ZhouDepartment of Radiation Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Kangsheng GuDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Bangjie ChenDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Yiwen JiaDepartment of Gastroenterology, The Third Affiliated Hospital of Anhui Medical University (Hefei First People's Hospital), Hefei, Anhui, China.ORCID 0009-0009-7696-650

Funding

Anhui Traditional Chinese Medicine Inheritance and innovation research project 2024CCCX228Basic and Clinical Cooperation Promotion Plan of Anhui Medical University 2023cy021Natural Science Research Major Project of Anhui Educational Committee 2023AH040077Natural Science Research Project of Anhui Educational Committee 2024AH050702
6 · The paper itself

Abstract

backgroundTumors are a major threat to human life and health. Neutrophil extracellular traps (NETs) have become a research focus in this context, especially regarding their role in tumor progression. Since the concept of NETs was introduced in 2004, its implications for tumor research have attracted significant scholarly attention. This study aims to explore research trends and cutting-edge hotspots in NETs and tumors through bibliometric analysis and provide new ideas for clinical applications.

methodsWe searched for literature on NETs and tumors published between 2004 and 2023 using the Web of Science database. Microsoft Excel 2019 was used for statistical analysis of influential articles, journals, authors, organizations, countries, and co-cited references. VOSviewer (version 1.6.16) and CiteSpace (V.5.8.R3) were employed for visualizing research data.

resultsThe analysis covered 790 articles authored by 4768 individuals from 1134 organizations in 56 countries. China and the United States are the leading contributors. The mechanism of NETs in tumor occurrence and development is likely linked to coagulation, inflammation, and infection. Hot topics in research include dendritic cells and thrombosis, with a shift from laboratory studies to clinical applications, suggesting a growing focus on treatment over etiology.

conclusionThis study offers the most comprehensive bibliometric analysis of NETs and tumors to date. Future research may focus on developing targeted therapies that block the interaction between NETs and tumors, offering a new direction for cancer treatment.

Indexed as

BibliometricsBiomedical ResearchExtracellular TrapsNeoplasmsNeutrophilsHumansbibliometricsglobal trendsneutrophil extracellular traps (NETs)thrombosistumor

Identifiers

PMID41686573
PMCPMC12908809

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.