Evidence mapPaperPMID 41687017Full record

ReviewComprehensive Physiology2026

The Vascular-Immune Cells Crosstalk and Microenvironment in Pulmonary Hypertension.

Lola Navarro-Llinares, Bertha García-León, Laura de la Bastida-Casero, Eduardo Oliver

Abstract readReview
In one paragraph

Review in Comprehensive Physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lola Navarro-LlinaresCenter for Biological Research Margarita Salas (CIB), CSIC, Madrid, Spain.
Bertha García-LeónCenter for Biological Research Margarita Salas (CIB), CSIC, Madrid, Spain.
Laura de la Bastida-CaseroCenter for Biological Research Margarita Salas (CIB), CSIC, Madrid, Spain.
Eduardo OliverCenter for Biological Research Margarita Salas (CIB), CSIC, Madrid, Spain.ORCID 0000-0001-9340-882X

Funding

Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares CV24PI04/2024Comunidad de Madrid PIPF-2022/SAL-GL-24824Consejo Superior de Investigaciones Científicas 20222AT010Consejo Superior de Investigaciones Científicas 2025AEP161Fundació la Marató de TV3 202336-30-31Fundación Contra la Hipertensión PulmonarMinisterio de Ciencia, Innovación y Universidades/Agencia Estatal de Investigaci PID2021-123167OB-I00Ministerio de Ciencia, Innovación y Universidades/Agencia Estatal de Investigaci PID2024-159407OB-I00Ministerio de Ciencia, Innovación y Universidades/Agencia Estatal de Investigaci PRE2022-104403Ministerio de Ciencia, Innovación y Universidades/Agencia Estatal de Investigaci RED2022-134299-T
6 · The paper itself

Abstract

Pulmonary hypertension is a disease of the lung vasculature, which eventually leads to heart dysfunction. Despite the advances in the discovery and development of new treatments, most of them are aimed to palliate symptoms. Thus, it is crucial to identify novel potential targets directly acting on vascular remodeling. Further understanding of this pathological event is needed to completely describe the disease's mechanisms and effectively generate therapeutical strategies able to cure the disease. Here, we propose an integrative perspective of studying pulmonary hypertension based on the interactions between the vascular cells and their surroundings. This review describes the crosstalk between vascular cells and immune cells in the diseased vasculature, highlighting the central role of this axis and the importance of healthy cell-to-cell communication. Furthermore, we discuss the possibility of considering the pulmonary microenvironment as a key pathological factor in pulmonary hypertension.

Indexed as

Cellular MicroenvironmentHypertension, PulmonaryAnimalsCell CommunicationEndothelial CellsHumansVascular Remodelingcrosstalkendothelial cellsimmune cellsmicroenvironmentpulmonary hypertensionsmooth muscle cellsvascular remodeling

Identifiers

PMID41687017
PMCPMC12904660

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.