Evidence map›Paper›PMID 41688504›Full record

ArticleScientific reports2026

Multifunctional pectin derivatives as anticancer agents in colorectal cancer via synthesis, computational insights, and modulation of NRF2/HO-1, HIF-1α, and VEGF/PDGF-D signaling pathways.

Ghada H Elsayed, Asmaa M Fahim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ghada H ElsayedHormones Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, P.O. Box.12622, Cairo, Egypt. gh.hamdi@nrc.sci.eg.
Asmaa M FahimDepartment of Green Chemistry, National Research Centre, Dokki, P.O. Box.12622, Cairo, Egypt. asmaamahmoud8521@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This research describes the design, synthesis, characterization, and biological assessment of new Pectin-based Hydrazide and Oxadiazole derivatives as possible anticancer agents. The chemical modification of native Pectin was accomplished using a sequence of esterification, Hydrazide formation, and cyclization with carbon disulfide to yield Pectin Hydrazide (3) and Pectin Oxadiazole (5), confirmed using FT-IR,

Indexed as

Antineoplastic AgentsColorectal NeoplasmsPectinsSignal TransductionCaco-2 CellsHeme Oxygenase-1Hep G2 CellsHumansHypoxia-Inducible Factor 1, alpha SubunitMolecular Docking SimulationNF-E2-Related Factor 2Reactive Oxygen SpeciesVascular Endothelial Growth Factor AAntineoplastic AgentsHeme Oxygenase-1HIF1A protein, humanHMOX1 protein, humanHypoxia-Inducible Factor 1, alpha SubunitNFE2L2 protein, humanNF-E2-Related Factor 2PectinsReactive Oxygen SpeciesVascular Endothelial Growth Factor AVEGFA protein, humanAngiogenesisColorectal cancerCytotoxicityOxidative stressPectin derivativesTheoretical studies

Identifiers

PMID41688504
PMCPMC12910068

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.