Evidence map›Paper›PMID 41689119›Full record

ArticleJournal of ovarian research2026

Single-cell dissection of regulated cell death dynamics in ovarian aging.

Qianyu Zhang, Yuanqu Zhao, Tong Wu, Gang Chen, Shixuan Wang, Mo Li, Jinjin Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ovarian research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qianyu ZhangDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
Yuanqu ZhaoDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
Tong WuDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
Gang ChenDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
Shixuan WangDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
Mo LiDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. limo_Rachel@163.com.
Jinjin ZhangDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. jinjinzhang@tjh.tjmu.edu.cn.

Funding

Interdisciplinary Research Program of HUST 2025JCYJ034National Natural Science Foundation of China 82471678Natural Science Foundation of Hubei Province 2025AFB489
6 · The paper itself

Abstract

backgroundOvarian aging drives declining fertility, premature menopause, and systemic age-related diseases. Multiple different types of regulated cell death (RCD) pathways have been identified and play integral roles in diverse physiological and pathological processes. However, the RCD landscape of ovarian aging remains uncharacterized at single-cell resolution.

resultsHere, we conducted single-cell RNA sequencing (scRNA-seq) on murine ovaries across aging (3, 9, 12 and 15 months), and mapped pan-RCD dynamics, including apoptosis, ferroptosis, parthanatos, and ten other pathways, revealing cell-type-specific RCD trajectories. These pathways exhibited distinct changes with ovarian aging, highlighting cell heterogeneity. Notably, apoptosis and parthanatos pathways demonstrated high correlations and rates of change with advancing age. Parthanatos was particularly notable for exhibiting one of the steepest age-associated increases. Cross-species validation using human ovarian scRNA-seq and GTEx V8 transcriptomics confirmed conserved parthanatos upregulation with age, negatively correlating with the expression levels of key enzymes in hormone synthesis.

conclusionsThe study deciphers the RCD patterns in murine and human ovarian aging, nominating parthanatos as a targetable node for combating ovarian aging and enhancing female fertility.

Indexed as

AgingOvarySingle-Cell AnalysisAnimalsApoptosisCell DeathFemaleGene Expression ProfilingHumansMiceSingle-Cell Gene Expression AnalysisAgingGene expression profilingOvaryParthanatos.Regulated cell deathSingle-cell RNA sequencing

Identifiers

PMID41689119
PMCPMC13005338

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.