Evidence map›Paper›PMID 41689121›Full record

ReviewGenome biology2026

Hidden in plain sight: illuminating the tRNA landscape by sequencing.

Katherine Marlow, Zhangli Su

Abstract readReview
In one paragraph

Review in Genome biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Katherine MarlowDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL, 35233, USA.
Zhangli SuDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL, 35233, USA. zsu@uab.edu.

Funding

UAB Predoctoral Training Grant in Translational and Molecular SciencesT32GM135028 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Mythreye Karthikeyan, RAKESH P. PATEL · 2021 to 2026
$1.6M
The role of small RNA modifications in gliomaR00CA259526 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SU, ZHANGLI · 2023 to 2025
$708k
NCI NIH HHS R00 CA259526NIGMS NIH HHS T32 GM135028NIH HHS R00CA259526NIH HHS T32GM135028
6 · The paper itself

Abstract

Transfer RNAs (tRNAs) are essential for decoding mRNAs into proteins and are increasingly recognized as dynamic regulators of gene expression. Their function is shaped by intricate layers of post-transcriptional processing, modification, aminoacylation, and fragmentation, all of which have been implicated in human disease. Recent advances in high-throughput sequencing have transformed our ability to profile tRNAs and their associated modifications, uncovering their roles in cancer, neuronal function, immune response, and stress response. In this review, we summarize emerging tRNA sequencing technologies and highlight how these approaches reveal fundamental insights into tRNA regulation and its therapeutic potential.

Indexed as

High-Throughput Nucleotide SequencingRNA, TransferSequence Analysis, RNAAnimalsHumansRNA Processing, Post-TranscriptionalRNA, TransferGenomicsNanoporeRNA modificationTranslationTRNATRNA-derived fragments

Identifiers

PMID41689121
PMCPMC13005431

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.