Evidence map›Paper›PMID 41689452›Full record

ArticlemAbs2026

ASD: antigen-specific antibody database.

Arkadiusz Czerwiński, Paweł Dudzic, Konrad Wójtowicz, Igor Jaszczyszyn, Weronika Bielska, Sonia Wrobel, Samuel Demharter, Roberto Spreafico, Victor Greiff, Konrad Krawczyk

Abstract read
In one paragraph

Article in mAbs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Arkadiusz CzerwińskiR&D Department, NaturalAntibody, Szczecin, Poland.ORCID 0009-0002-8375-5144
Paweł DudzicR&D Department, NaturalAntibody, Szczecin, Poland.ORCID 0009-0006-3849-7640
Konrad WójtowiczR&D Department, NaturalAntibody, Szczecin, Poland.
Igor JaszczyszynR&D Department, NaturalAntibody, Szczecin, Poland.
Weronika BielskaR&D Department, NaturalAntibody, Szczecin, Poland.
Sonia WrobelR&D Department, NaturalAntibody, Szczecin, Poland.
Samuel DemharterData Science Department, Genmab, Utrecht, Netherlands.
Roberto SpreaficoData Science Department, Genmab, Utrecht, Netherlands.
Victor GreiffLaboratory for Computational and Systems Immunology, Faculty of Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0003-2622-5032
Konrad KrawczykR&D Department, NaturalAntibody, Szczecin, Poland.ORCID 0000-0003-0697-5522

Funding

Development of a data extraction technology from scientific literature using large language models for the discovery of therapeutic antibodies GRANT NO. FEPZ.01.01-IZ.00-0008/23
6 · The paper itself

Abstract

The development of computational models addressing therapeutic antibodies faces significant challenges. Particularly, the prediction of binding affinity across a diverse set of measurements, due to the scarcity of data. A critical data element is the set of antibody-antigen interaction pairs associated with sequences. To address this issue, we developed the Antigen Specific Antibody Database (ASD, https://naturalantibody.com/agab/), a database aggregating antibody-antigen interaction data from multiple studies with standardized formatting and annotations. Our dataset compilation strategy resulted in data from 15 distinct sources, resulting in 1,097,946 unique antibody-antigen interactions (with 9575 unique antigens). The ASD captures diverse affinity measures and qualitative binding assessment, along with metadata including UniProt and PDB identifiers, target protein names, confidence levels, and experimental conditions such as type of measured affinity, source organism, and germline genes. Through this integration drive, we make available an ample resource of interaction data gathered from the public domain to act as a foundation for model development and further data generation.

Indexed as

AntibodiesAntigensDatabases, ProteinAnimalsAntibody AffinityComputational BiologyHumansImmunoinformaticsAntibodiesAntigensAntibody designbinding affinitybioinformaticscomputational immunologydatabasesdrug discovery

Identifiers

PMID41689452
PMCPMC12915772

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.