ReviewInvestigational new drugs2026
Patient-derived tumor organoids for new drug development: promises and challenges.
Review in Investigational new drugs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Patient-Derived Organoids in Gastrointestinal Disease: Current Applications, Limitations, and Future Perspectives.International journal of molecular sciences · 2026Review
- Natural Killer Cell Immunotherapy in Solid Tumors: Microenvironmental Obstacles and Translational 3D Models.Biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The development of antitumor drugs is affected by various unfavorable factors, including long cycles of research and development, large differences in drug efficacy in vivo, and efficacy differences in individuals. Patient-derived tumor organoids (PDTOs), a novel preclinical model in cancer research, are three-dimensional microstructures differentiated from stem cells, with the capability of self-organizing into micro-organs that resemble the original tumor tissues. They have been demonstrated to faithfully recapitulate the biological and molecular features of the original tumor while preserving the tumor heterogeneity. Recently, PDTOs show great potential in drug screening and new drug development. In this review, we overviewed the types of organoids, application of PDTOs in developing new drugs, as well as their challenges and opportunities to provide powerful insights into drug development.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.