Evidence map›Paper›PMID 41690959›Full record

Articlenpj aging2026

MicroRNA profiles in plasma-derived extracellular vesicles across the human lifespan.

C Ráez-Meseguer, C Navas-Enamorado, X Capó, A M Galmes-Panades, A Molina de la Llave, M Mendez-Varela, M Martinez-Calvo, A Bennasar-Arbos, A Sánchez-Polo, L Masmiquel and 4 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in npj aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

C Ráez-MeseguerGroup of Cell Therapy and Tissue Engineering (TERCIT, Research Institute on Health Sciences (IUNICS), University of the Balearic Islands, Palma, Spain.
C Navas-EnamoradoTranslational Research in Aging and Longevity (TRIAL) Group, Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.
X CapóDepartment of Fundamental Biology and Health Sciences, University of the Balearic Islands, Palma, Spain.
A M Galmes-PanadesPhysical Activity and Sport Sciences Research Group (GICAFE), Institute for Educational Research and Innovation (IRIE), University of the Balearic Islands, Palma, Spain.
A Molina de la LlaveTranslational Research in Aging and Longevity (TRIAL) Group, Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.
M Mendez-VarelaTranslational Research in Aging and Longevity (TRIAL) Group, Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.
M Martinez-CalvoTranslational Research in Aging and Longevity (TRIAL) Group, Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.
A Bennasar-ArbosTranslational Research in Aging and Longevity (TRIAL) Group, Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.
A Sánchez-PoloTranslational Research in Aging and Longevity (TRIAL) Group, Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.
L MasmiquelVascular and Metabolic Pathologies Group, Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.
M Torrens-MasHealth Research Institute of the Balearic Islands (IdISBa), Palma, Spain.
M MonjoGroup of Cell Therapy and Tissue Engineering (TERCIT, Research Institute on Health Sciences (IUNICS), University of the Balearic Islands, Palma, Spain.
J M RamisGroup of Cell Therapy and Tissue Engineering (TERCIT, Research Institute on Health Sciences (IUNICS), University of the Balearic Islands, Palma, Spain. joana.ramis@uib.es.
M Gonzalez-FreireTranslational Research in Aging and Longevity (TRIAL) Group, Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain. martagonzalezfreire@gmail.com.

Funding

Agencia Española de Investigación, Spain CNS2022-135110Govern de les Illes Balears FOLIUM program-19/01 and, SYNERGIA program SYN22/04Instituto de Salud Carlos III MS19/00201Instituto de Salud Carlos III PI21/01480
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are key mediators of intercellular communication and may reflect physiological changes during aging. We analyzed plasma-derived EVs from a healthy aging cohort stratified by age, using size exclusion chromatography, surface profiling, nanoparticle tracking, and small RNA sequencing. While EV size and concentration remained largely unchanged, older individuals showed shifts in EV immunophenotype consistent with immunosenescence and displayed distinct miRNA signatures enriched in muscle-specific and metabolism-related miRNAs, including miR-206, miR-143-3p, miR-122-5p, and miR-20b-3p-linked to muscle, metabolic, and vascular function. Notably, miR-6529-5p, associated with neuroprotection, was elevated in aging. Target gene analysis revealed involvement in aging pathways such as Ras, VEGF, and MAPK signaling. EV miRNAs and particle counts correlated with biological aging markers, including GDF-15, visceral fat, and muscle quality. These findings highlight coordinated age-related changes in EVs reflecting musculoskeletal and metabolic aging and support their potential as minimally invasive biomarkers of biological aging and functional decline.

Identifiers

PMID41690959
PMCPMC12909829

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.