Anxiety severity moderates the relation between pineal parenchymal volume and objective sleep problems in peri-adolescent youth.

Francisco Fuertes, Macarena Lalama, Anthony Steven Dick, Amanda E Baker, Dana L McMakin, Aaron T Mattfeld

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Francisco FuertesDepartment of Psychology, Florida International University, AHC4-462, 11200 SW 8th Street, Miami, FL, 33199, USA.

Macarena LalamaDepartment of Psychology, Florida International University, AHC4-462, 11200 SW 8th Street, Miami, FL, 33199, USA.

Anthony Steven DickDepartment of Psychology, Florida International University, AHC4-462, 11200 SW 8th Street, Miami, FL, 33199, USA.

Amanda E BakerDepartment of Psychology, Florida International University, AHC4-462, 11200 SW 8th Street, Miami, FL, 33199, USA.

Dana L McMakinDepartment of Psychology, Florida International University, AHC4-462, 11200 SW 8th Street, Miami, FL, 33199, USA.

Aaron T MattfeldDepartment of Psychology, Florida International University, AHC4-462, 11200 SW 8th Street, Miami, FL, 33199, USA. amattfel@fiu.edu.

Funding

NIMH NIH HHS MH116005

6 · The paper itself

Abstract

Sleep problems are common in anxiety especially around the onset of adolescence ("peri-adolescence") when symptoms escalate and sleep changes. The pineal gland is a compelling target given its role in sleep behavior and associations with multiple disorders that report problems with sleep. We investigated pineal gland volume and anxiety severity in relation to objective measures of sleep derived from polysomnography in a group of peri-adolescents. Youth (N = 200; 10-13 years) were sampled across a continuum of anxiety severity, with special emphasis on social, generalized, and separation anxiety disorders, to capture variability in key risk profiles and behaviors. This study uses structural scans obtained from participants with polysomnography data (n = 135). Pineal glands were manually segmented into parenchymal and cyst compartments. Linear models were used to assess the interaction between anxiety severity and pineal parenchymal volume (PPV) on sleep onset latency (SOL), sleep efficiency (SE), and non-rapid eye movement (NREM) and REM duration. Analyses revealed significant interactions between anxiety severity and PPV on SOL, SE, and NREM duration but not REM duration; whereby elevated anxiety was associated with larger PPV and longer SOL and reduced SE and NREM duration. Pineal morphology may be a contributing factor to sleep problems in anxiety during peri-adolescence.

Indexed as

AnxietyPineal GlandSleep Wake DisordersAdolescentChildFemaleHumansMagnetic Resonance ImagingMaleOrgan SizePolysomnographySeverity of Illness IndexSleepAdolescenceAnxietyMRIPineal glandPolysomnography

Identifiers

PMID41691065

DOI10.1038/s41598-026-39349-y

PMCPMC12992583

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.