← Cardiac procedures & devices × cardiovascular events

Observational studyCardiovascular diabetology2026

Prognostic impact of metformin in diabetic patients undergoing a percutaneous coronary intervention (PCI): protective effect is modified by procedural complexity.

Zhihao Zheng et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedas reported · 2026

Not counted

Probably reduced cardiovascular events

−35%−47% to −21%

Bigger than 8 in 10 for cardiovascular events

As reported

HR 0.65, 95% CI 0.53–0.79

Range includes no effect

No clear effect on cardiovascular events

+0%−17% to +21%

Smaller than almost all for cardiovascular events

As reported

HR 1.00, 95% CI 0.83–1.21

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Went with fewer cardiovascular events

−20%−30% to −8%

Bigger than 4 in 10 for cardiovascular events

As reported

HR 0.80, 95% CI 0.70–0.92

Three numbers in the abstract

the abstract, start to end

… undergoing non-complex PCI (adjusted HR 0.65, 95% CI: 0.53-0.79), while such protective effect of metformin didn’t exist in complex PCI patients (adjusted HR 1.00, 95%CI: 0.83-1.21).

… incidence of 3-year MACCEs (adjusted HR 0.80, 95%CI 0.70-0.92) after …

← favours treatmentfavours comparator →
could be chance
Cardiovascular events
HR 0.650.53–0.79
Cardiovascular events
HR 0.800.70–0.92
Cardiovascular events
HR 1.000.83–1.21
MetforminCardiac procedures & devicesCardiovascular events
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1 paper cites it

2026
this papercites it
Full record →Abstract, authors, funding and every citing paper · PMID 41691210