Evidence map›Paper›PMID 41692008›Full record

ArticleJournal of applied toxicology : JAT2026

Acute and 28-Day Toxicity Evaluation of New Pleuromutilin Derivative 4g.

He-Chao Zhang, Zhun Li, Zhe Qin, Wen-Bo Ge, Ya-Jun Yang, Jian-Yong Li

Abstract read
In one paragraph

Article in Journal of applied toxicology : JAT, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

He-Chao ZhangCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China.
Zhun LiKey Laboratory of New Animal Drug of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Science of CAAS, Lanzhou, China.
Zhe QinKey Laboratory of New Animal Drug of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Science of CAAS, Lanzhou, China.
Wen-Bo GeKey Laboratory of New Animal Drug of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Science of CAAS, Lanzhou, China.ORCID 0000-0002-3012-9169
Ya-Jun YangKey Laboratory of New Animal Drug of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Science of CAAS, Lanzhou, China.
Jian-Yong LiCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China.ORCID 0000-0003-3317-0666

Funding

Science and Technology Innovation Project of CAAS 25-LZIHPS-02
6 · The paper itself

Abstract

A novel pleuromutilin derivative, compound 4g with a cyclobutyl side chain, was identified and found to have good antibacterial activity, including methicillin-resistant Staphylococcus aureus (MRSA) and Mycoplasma. In order to evaluate its safety profile, acute and 28-day oral toxicity studies were carried out. An acute toxicity study in rats revealed that the oral LD

Indexed as

Anti-Bacterial AgentsDiterpenesLiverAdministration, OralAlanine TransaminaseAnimalsDose-Response Relationship, DrugFemaleLethal Dose 50MaleNo-Observed-Adverse-Effect LevelPleuromutilinsPolycyclic CompoundsRatsRats, Sprague-DawleyToxicity Tests, AcuteAlanine TransaminaseAnti-Bacterial AgentsDiterpenesPleuromutilinsPolycyclic Compounds28‐day oral toxicityacute toxicityantibacterial activitypleuromutilin derivative

Identifiers

PMID41692008
PMCPMC13432738

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.