Complementary Sensitivity of Fixed-Time and Fixed-Oscillation Regimes to Exchange and Structural Disorder in the Human Brain Revealed Using Oscillating-Gradient Diffusion MRI With Ultra-Strong Gradients.
Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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5 · Who and what money
Authors and funding
9 authors.
Dongsuk SungAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.ORCID 0000-0001-6287-2144
Kwok-Shing ChanAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.ORCID 0000-0001-8427-169X
Julianna GeroldAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.ORCID 0009-0000-5460-6591
Wen ZhongSchool of Biomedical Engineering, Tsinghua University, Beijing, China.
Jialan ZhengSchool of Biomedical Engineering, Tsinghua University, Beijing, China.ORCID 0009-0003-0603-4228
Qiyuan TianSchool of Biomedical Engineering, Tsinghua University, Beijing, China.ORCID 0000-0002-8350-5295
Hua GuoSchool of Biomedical Engineering, Tsinghua University, Beijing, China.ORCID 0000-0002-0482-1493
Susie Y HuangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.ORCID 0000-0003-2950-7254
Hong-Hsi LeeAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.ORCID 0000-0002-3663-6559
Funding
CONNECTOME 2.0: DEVELOPING THE NEXT GENERATION HUMAN MRI SCANNER FOR BRIDGING STUDIES OF THE MICRO-, MESO- AND MACRO-CONNECTOMEU01EB026996 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BASSER, PETER J., HUANG, SUSIE YI · 2018 to 2022
$14.2M
Training and Dissemination CoreP41EB030006 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Susie Yi Huang · 2020 to 2026
$10.9M
Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Connectome 2.0: A BRAIN Technology Integration and Dissemination Resource for Ultra-High Gradient Magnetic Resonance Imaging of Human Brain Circuits Across ScalesU24NS137077 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Susie Yi Huang · 2024 to 2026
$4.0M
Toward a Validated in Vivo Imaging Marker of Axonal Damage Predictive of Progressive Disability in Multiple SclerosisR01NS118187 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI HUANG, SUSIE YI · 2021 to 2025
$2.8M
Revealing tissue microstructure in the brain gray matter in Alzheimer's disease using in vivo high-gradient diffusion MRIDP5OD031854 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, HONG HSI · 2021 to 2025
$2.1M
Developing a validated biomarker of cortical neurodegeneration in Alzheimer's disease using high-gradient diffusion MRIR21AG085795 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HUANG, SUSIE YI · 2024 to 2025
purposeOscillating-gradient spin-echo (OGSE) diffusion MRI probes cell geometry and membrane integrity through the frequency-dependence of kurtosis, but prior studies have reported inconsistent findings depending on how frequency is varied. We compared frequency-dependent kurtosis in the human brain under two regimes: varying frequency with fixed total waveform duration (fixed-
methodsEleven healthy volunteers were scanned on the 3 T Connectome 2.0 system with OGSE using 500 mT/m gradients. Mean kurtosis (MK) was measured using three fixed-
resultsDistinct frequency-dependence was observed between regimes. In fixed-
conclusionFixed-
Indexed as
BrainDiffusion Magnetic Resonance ImagingAdultFemaleHumansImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedMaleReproducibility of ResultsSensitivity and SpecificityWhite Matter
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Complementary Sensitivity of Fixed-Time and Fixed-Oscillation Regimes to Exchange and Structural Disorder in the Human Brain Revealed Using Oscillating-Gradient Diffusion MRI With Ultra-Strong Gradients. · full record | Socratic