Evidence map›Paper›PMID 41692849›Full record

ArticleVirchows Archiv : an international journal of pathology2026

Outside canonical BRAF p.V600E Box: 7 novel BRAF gene fusions in BRAF p.V600E WT papillary thyroid carcinoma.

Nathan McGrath, Li Liang, Rania Bakkar, Thomas J Gernon, Ellie Maghami, Michelle Afkhami, Diana Bell

Abstract read
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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nathan McGrathDepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, 15231, USA.
Li LiangDepartment of Pathology and Immunology, Department of Pathology and Laboratory Medicine, Baylor College of Medicine, Ben Taub Hospital, Harris Health System, Houston, TX, 77030, USA.
Rania BakkarDepartment of Anatomic Pathology, City of Hope Cancer Center, Duarte, CA, 91010, USA.
Thomas J GernonDepartment of Surgery, Head and Neck Surgery, City of Hope Cancer Center, Duarte, CA, 91010, USA.
Ellie MaghamiDepartment of Surgery, Head and Neck Surgery, City of Hope Cancer Center, Duarte, CA, 91010, USA.
Michelle AfkhamiDepartment of Anatomic Pathology, City of Hope Cancer Center, Duarte, CA, 91010, USA.
Diana BellHead and Neck/Endocrine Pathology Center of Excellence, Division of Anatomic Pathology and Otolaryngology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA, 15231, USA. belldiana@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BRAF, when mutated at V600E, is a well-known potent early oncogenic driver in papillary thyroid carcinoma (PTC), with potential prognostic and therapeutic implications. Non-V600E mutations are less common and without clear functional or therapeutic significance. One class of non-V600E mutations is BRAF gene fusions, which typically involve the C-terminal kinase domain of BRAF joined to a wide repertoire of potential N-terminal fusion partners. The aim of this study was to employ a sequential algorithmic approach to identify patients with BRAF fusions based on an integrated analysis of histologic, immunohistochemistry (IHC), and molecular (NGS) features of BRAF-rearranged PTCs. Nine patients with PTC previously scrutinized as BRAF V600E negative by IHC were analyzed by NGS. The studied 9 cases showed conventional PTC growth; 2 cases displayed a minor high-grade component (tall cell and hobnailing, < 20%), 1 case qualified as high-grade differentiated thyroid carcinoma (presence of necrosis and mitotic activity > 5 MF/ 2 mm

Indexed as

BRAFDriversFusionsMutationsPapillary thyroid carcinoma

Identifiers

PMID41692849

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.