ArticleScience China. Life sciences2026
Butyrate supplementation in sows promotes offspring embryonic muscle development by upregulating HDAC-mediated H3K27ac levels and myogenic gene expression.
Article in Science China. Life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Butyrate, an important short-chain fatty acid, plays multiple biological roles in animal growth and development. Our previous studies have revealed that SYISL knockout in mother mice can enhance embryonic muscle development in their offspring by influencing the maternal gut microbiota and its metabolite, butyric acid. However, it remains unclear whether butyrate supplementation in sows can enhance the total muscle fiber number in piglets. In this study, we confirmed that supplementing gestating sow diets with 0.05% sodium butyrate significantly increased birth weight and total muscle fiber number in the longissimus dorsi muscle of their offspring. Further studies revealed that maternal butyrate may influence offspring embryonic myogenesis through remodeling maternal gut microbiota composition and enhancing offspring intestinal barrier function. Metabolomic and transcriptomic analyses in the longissimus dorsi muscle revealed that maternal butyrate supplementation in sows modulates arginine and proline metabolism in skeletal muscles of offspring. Integrated analyses of transcriptomics, H3K27ac Cut&Tag in pig muscle, and in vitro experiments demonstrated that maternal butyrate increases HDAC-mediated H3K27ac levels in the longissimus dorsi muscle of piglets and promotes the expression of myogenic genes by enhancing H3K27ac enrichment in their regulatory regions, such as MyoG, Myh7, and Acta1. These results uncover a new mechanism through which butyrate promotes the development of embryonic muscle and support a theoretical foundation for increasing the total muscle fiber number in piglets.
Indexed as
Identifiers
41692939What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.