Evidence map›Paper›PMID 41692987›Full record

ArticleBioinformatics (Oxford, England)2026

pyBiodatafuse: extending interoperability of data using modular queries across biomedical resources.

Yojana Gadiya, Javier Millán Acosta, Ammar Ammar, Alejandro Adriaque Lozano, Delano Wetstede, Dominik Martinát, Ana Claudia Sima, Hailiang Mei, Egon Willighagen, Tooba Abbassi-Daloii

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yojana GadiyaEnveda, Boulder, Colorado, 80301, United States.ORCID 0000-0002-7683-0452
Javier Millán AcostaDepartment of Translational Genomics, NUTRIM Institute of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, 6229, The Netherlands.ORCID 0000-0002-4166-7093
Ammar AmmarDepartment of Translational Genomics, NUTRIM Institute of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, 6229, The Netherlands.ORCID 0000-0002-8399-8990
Alejandro Adriaque LozanoMaastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, 6229, The Netherlands.
Delano WetstedeFaculty of Life Science & Technology, Leiden University of Applied Sciences, Leiden, 2333, The Netherlands.
Dominik MartinátDepartment of Physical Chemistry, Palacky University, Olomouc, 779 00, Czech Republic.ORCID 0000-0001-6611-7883
Ana Claudia SimaSIB Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland.ORCID 0000-0003-3213-4495
Hailiang MeiSequencing Analysis Support Core, Leiden University Medical Center (LUMC), Leiden, 2333, The Netherlands.ORCID 0000-0003-1781-5508
Egon WillighagenDepartment of Translational Genomics, NUTRIM Institute of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, 6229, The Netherlands.ORCID 0000-0001-7542-0286
Tooba Abbassi-DaloiiDepartment of Translational Genomics, NUTRIM Institute of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, 6229, The Netherlands.ORCID 0000-0002-4904-3269

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

motivationIntegrating omics data analysis with publicly available databases is crucial for unravelling complex biological mechanisms. However, this integration process is often intricate and time-consuming due to the diversity and complexity of the data involved. Achieving consistent harmonization across data types is challenging when managing disparate formats and sources. To address these issues, we introduce pyBiodatafuse, a query-based Python tool designed to integrate biomedical databases. This tool establishes a modular framework that simplifies data wrangling, enabling the creation of context-specific knowledge graphs (KGs) while supporting graph-based analyses.

resultsWe developed a pipeline for generating context-specific knowledge graphs dynamically, allowing users to create KGs on the fly from a set of gene or metabolite identifiers. pyBiodatafuse features a user-friendly interface that streamlines this process, making it accessible even to researchers without extensive computational expertise. Additionally, the tool offers plugins for widely used platforms such as Cytoscape, Neo4j, and GraphDB, enabling local hosting of resulting property and RDF graphs. This versatility ensures that generated KGs can be efficiently utilized within diverse research workflows. To demonstrate its potential, we used pyBiodatafuse to create a graph for post-COVID syndrome using differential gene expression data, showcasing its ability to build adaptable and context-specific knowledge representations. Thus, pyBiodatafuse sets the stage for streamlined data integration, empowering researchers to focus on discovery and analysis without being hindered by data management complexities. AVAILABILITY AND IMPLEMENTATION: pyBiodatafuse is open-source, with its source code and PyPi package available at https://github.com/BioDataFuse/pyBiodatafuse and https://pypi.org/project/pyBiodatafuse/. The user interface can be accessed at https://biodatafuse.org/. Additionally, a release has been made on Zenodo at https://doi.org/10.5281/zenodo.18468942.

Indexed as

Computational BiologySoftwareDatabases, FactualUser-Computer Interface

Identifiers

PMID41692987
PMCPMC12949461

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.