ReviewIranian journal of child neurology2026
Metabolic-Immune Crosstalk in Pediatric Rheumatology: From Pathogenesis to Precision Therapy.
Review in Iranian journal of child neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immune system and metabolic pathways are strongly interconnected, influencing each other in both physiological and pathological contexts. Nutrient signaling and cellular energy levels significantly impact immune system function, from activation to differentiation and survival. In children, where both the immune and metabolic systems are still developing, disturbances in this balance can markedly influence disease manifestation and treatment response. Recent advances in immunometabolism have revealed that metabolic dysfunction is not merely a consequence of inflammation but can also serve as a primary driver of immune dysregulation. Accordingly, this review explores how metabolic disturbances may mimic or modify rheumatic diseases, and, conversely, how immune-mediated disorders can disrupt metabolic homeostasis. Understanding this bidirectional relationship provides novel insights into pathogenesis and opens avenues for metabolism-based diagnostic and therapeutic strategies in pediatric rheumatology.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.