ArticleFrontiers in immunology2026
Hepatocyte growth factor as a driver of synovial inflammation and therapeutic resistance in rheumatoid arthritis.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Previous studies have demonstrated that hepatocyte growth factor (HGF) is implicated in treatment resistance in rheumatoid arthritis (RA). This study aimed to elucidate the mechanistic role of HGF in synovial inflammation and assess the therapeutic potential of targeting the HGF-c-Met axis. Methods: Plasma HGF levels were measured in 66 RA patients. The expression of HGF and its receptor, c-Met, in synovial tissue was assessed using publicly available single-cell RNA sequencing data and immunostaining. The effects of HGF on synovial fibroblasts were examined through bulk RNA sequencing, immunostaining, and quantitative PCR. The therapeutic efficacy of the c-Met inhibitor savolitinib was evaluated in a mouse model of arthritis. Results: Plasma HGF levels were significantly elevated in RA patients ( Conclusion: HGF primarily acts on synovial fibroblasts, driving an IL-6-mediated inflammatory amplification loop that may contribute to therapeutic resistance in RA. Targeting the HGF-c-Met pathway could represent a novel strategy for overcoming treatment refractoriness in RA.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.