Evidence map›Paper›PMID 41694550›Full record

ArticlePain reports2026

Pulsed radiofrequency of S2-4 nerve roots vs ganglion impar neurolysis for severe perineal cancer pain.

Sayed M Abed, Taher S Thabet, Mostafa A Ibrahim, Ahmed F Gad, Fatma H Elshamy, Doaa Abd Eltwab, Mohamed A Wadod, Walaa Y Elsabeeny

Abstract read
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In one paragraph

Article in Pain reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sayed M AbedDepartment of Anesthesia, Surgical Critical Care and Pain Management, National Cancer Institute, Cairo University, Cairo, Egypt.
Taher S ThabetDepartment of Anesthesia, Surgical Critical Care and Pain Management, National Cancer Institute, Cairo University, Cairo, Egypt.
Mostafa A IbrahimDepartment of Anesthesia, Surgical Critical Care and Pain Management, National Cancer Institute, Cairo University, Cairo, Egypt.
Ahmed F GadDepartment of Anesthesia, Surgical Critical Care and Pain Management, National Cancer Institute, Cairo University, Cairo, Egypt.
Fatma H ElshamyDepartment of Anesthesia, Surgical Critical Care and Pain Management, National Cancer Institute, Cairo University, Cairo, Egypt.
Doaa Abd EltwabDepartment of Anesthesia, Surgical Critical Care and Pain Management, National Cancer Institute, Cairo University, Cairo, Egypt.
Mohamed A WadodDepartment of Anesthesia, Surgical Critical Care and Pain Management, National Cancer Institute, Cairo University, Cairo, Egypt.
Walaa Y ElsabeenyDepartment of Anesthesia, Surgical Critical Care and Pain Management, National Cancer Institute, Cairo University, Cairo, Egypt.ORCID https://orcid.org/0000-0003-3047-6926

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Perianal and perineal-related cancer pain is deemed severe in most patients with cancer, and its management poses a significant challenge due to rich innervation of this region. Objectives: This study compared the analgesic efficacy of bilateral selective pulsed radiofrequency (PRF) of sacral nerve roots (S2-S4) with ganglion impar neurolysis (GIN) in patients experiencing severe perianal and perineal cancer pain. Methods: Forty patients with severe perineal or perianal cancer pain, defined by a visual analogue scale (VAS) score ≥7, were randomized to 1 of 2 groups. Both procedures were performed under fluoroscopic guidance: the PRF group received bilateral selective PRF of sacral nerve roots (S2-S4), whereas the GIN group underwent ganglion impar neurolysis using a 6% phenol in saline injection. The primary outcome was the VAS score at 4 weeks. Results: Both groups showed significant reductions in VAS scores up to 12 weeks post-treatment compared to baseline ( Conclusion: Bilateral PRF of sacral nerve roots (S2-S4) resulted in more analgesic efficacy and improved quality-of-life compared to GIN in patients with severe perineal and perianal cancer pain, despite higher rate of injection site discomfort.

Indexed as

CancerGanglion imparNeurolysisPainPulsed radiofrequency

Identifiers

PMID41694550
PMCPMC12900185

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.